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Version 2.0 formulas releasing soon · Single batch every time — every batch reformulated and matched to the latest scientific evidence · 166 evidence-based compounds across 30 products.Version 2.0 releasing soon · Single batch every time · 166 compounds across 30 products.
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Ingredient Research Tool

Every ingredient we use, with the evidence behind it

166 ingredients across the Version 2.0 line — branded form, studied dose, what the human trials show, who should be careful, and which formula it sits in.

Tier 1–2 · human trialsTier 3–4 · mechanistic, traditional or emergingLiposomal / enhanced delivery

Foundation nutrients

Tier 2

Betaine anhydrous (TMG)

RCTs: 2.5 g/day improved body composition and power in trained men; lowers homocysteine (pairs with

In: Ultimate Morning

Tier 1

Choline (as choline bitartrate)

Essential nutrient; AI 550 mg/day

In: Ultimate Morning

Tier 1

CocoaVia® cocoa flavanol extract (Cocoapro™ process, 500 mg flavanols)

COSMOS RCT (n=21,442): cocoa extract 500 mg flavanols/day reduced CVD death 27%; FMD and BP

In: Ultimate Morning

Tier 2

D-ribose

RCTs: fatigue/fibromyalgia symptom and exercise recovery; heart-failure diastolic

In: Ultimate Morning

Tier 3

Ionic trace minerals (ConcenTrace®, 72 minerals)

Mineral repletion rationale; limited

In: Ultimate Morning

Tier 1Liposomal

Liposomal vitamin C (PureWay-C® liposomal)

PureWay-C PK: faster uptake and retention vs ascorbic acid; vitamin C essential for collagen

In: Ultimate Morning · Ultimate Recovery

Tier 1

Methylated B-complex (B1 benfotiamine 50 mg, B2 R5P 10 mg, B3 niacinamide 30 mg, B5 50 mg, B6 P5P 15 mg, biotin 300 mcg, folate Quatrefolic® 400 mcg DFE, B12 methyl/adenosyl 500 mcg)

Essential; active forms bypass MTHFR/conversion; Quatrefolic PK superior to folic

In: Ultimate Morning

Tier 2Standalone candidate

Molecular hydrogen tablet (magnesium-based, 8 ppm)

RCTs: reduced inflammation markers and fatigue in athletes; metabolic syndrome trial

Tier 1

Taurine

Meta-analyses: BP, lipids, exercise performance; longevity signal in animals (2023

In: Ultimate Morning

Fat-soluble vitamins & carotenoids

Tier 2

AstaPure® natural astaxanthin (Haematococcus)

RCTs: skin photoprotection (4–12 mg), eye fatigue, exercise

In: D·A·K·E

Tier 1

Lutein + zeaxanthin (Lutemax 2020®)

AREDS2 and LAMA trials: macular pigment, visual

In: D·A·K·E

Tier 3

LYSOVETA® LPC-bound omega-3 (EPA/DHA)

Mfsd2a-transport rationale for brain DHA; human PK studies; outcome RCTs

In: D·A·K·E

Tier 2

Saffron extract (affron®, 3.5% Lepticrosalides®)

RCTs at 28 mg: mood, sleep; saffron for eye health at 20–30

In: D·A·K·E

Tier 1

Vitamin A (as retinyl palmitate)

Essential; pairs with D for receptor

In: D·A·K·E

Tier 1

Vitamin D3 (cholecalciferol, lichen-derived)

Deficiency correction RCTs; 5,000 IU/day typical for serum 50–80

In: D·A·K·E

Tier 1

Vitamin K1 (phytonadione)

Essential;

In: D·A·K·E

Tier 2

Vitamin K2 as MK-4

Japanese osteoporosis trials used 45 mg; low-dose MK-4 raises carboxylated

In: D·A·K·E

Tier 1

Vitamin K2 as MK-7 (MenaQ7®)

3-yr RCT (n=244): 180 mcg/day improved arterial stiffness and bone strength (Knapen

In: D·A·K·E

Minerals & electrolytes

Tier 3

Aquamin® Mg seawater magnesium hydroxide

Bioavailability study (PubMed 30018220) shows good Mg retention; trace-mineral

In: Ultimate Minerals

Tier 2

Boron (as boron glycinate)

RCTs at 3–10 mg: raised free testosterone, lowered SHBG and hs-CRP in men; bone/joint

In: Ultimate Minerals

Tier 2

Chromium (as chromium picolinate)

Meta-analyses: modest glycemic benefit in

In: Ultimate Minerals

Tier 1

Copper (as copper bisglycinate)

Essential; balances

In: Ultimate Minerals

Tier 3

Humic/fulvic mineral complex (BioActive Carbon®)

Narrative reviews and 2025 safety/microbiota profiling; human trials sparse (NCT07579845 pending on epigenetic

In: Ultimate Minerals · Ultimate Morning

Tier 1

Iodine (as potassium iodide)

Essential; RDA 150

In: Ultimate Minerals

Tier 3

Magnesium acetyl-taurate

Raised brain Mg in rodents (PubMed 30761462); taurine co-benefit; human RCTs

In: Ultimate Minerals

Tier 1

Magnesium citrate

Highly bioavailable; multiple RCTs (BP,

In: Ultimate Minerals

Tier 3

Magnesium malate

Fibromyalgia pilot RCTs; malate feeds the Krebs cycle; good

In: Ultimate Minerals

Tier 3

Magnesium orotate

Heart-failure RCT (Stepura 2009) improved survival/symptoms at 6 g/day; small doses

In: Ultimate Minerals

Tier 1

Manganese (as manganese bisglycinate)

Essential cofactor

In: Ultimate Minerals

Tier 1

Molybdenum (as molybdenum glycinate)

Essential cofactor (sulfite

In: Ultimate Minerals

Tier 2

PrimaVie® purified shilajit (60% fulvic acid)

RCTs: 250/500 mg × 8 wk maintained strength after fatigue; 90-day trial raised total testosterone in healthy men (n=75); mitochondrial…

In: Ultimate Minerals

Tier 1

Selenium (as L-selenomethionine)

Essential; thyroid/antioxidant

In: Ultimate Minerals

Tier 1

Zinc (as zinc bisglycinate TRAACS®)

Essential; RCTs on immune/testosterone status in

In: Ultimate Minerals

Heart & circulation

Tier 3

Artichoke leaf (5% cynarin) + ginger root (5% gingerols) complex

Artichoke leaf extract meta-analyses show modest LDL/TG reduction; ginger lowers TG in small RCTs. Combination data limited to the branded…

In: Ultimate Heart

Tier 2

Bergamonte® bergamot polyphenolic fraction (38% BPF)

11 published human trials; 237-pt RCT at 500/1,000 mg × 30 d improved total/LDL cholesterol, TG and glucose vs placebo; 77-pt trial with…

In: Ultimate Heart

Tier 1

CardioAid® plant sterols

50+ years of trials; FDA-authorized health claim at ≥0.8 g/day plant sterols for reduced CHD risk; LDL −8–10% at 2

In: Ultimate Heart

Tier 3

CyanthOx30™ sea buckthorn (30% proanthocyanidins)

Sea buckthorn proanthocyanidins: biomarker trials on vascular and skin outcomes; limited branded human

In: Ultimate Blood Flow

Tier 2

DeltaGold® annatto tocotrienols (90% δ / 10% γ)

250 mg/day δ-tocotrienol improved lipid and inflammatory markers in several small RCTs (n≈31–60); 14-day crossover raised plasma δ-T3 and…

In: Ultimate Heart · D·A·K·E

Tier 3

Geranylgeraniol (GG-Gold®, from annatto)

Human pilot data on statin-associated muscle symptoms and testosterone support in men on statins; mechanistic rationale (mevalonate…

In: Ultimate Heart · D·A·K·E

Tier 2

Lyc-O-Mato® tomato complex (6% lycopene)

RCT in 60 treated hypertensives: standardized tomato extract (15 mg lycopene) lowered systolic BP and improved endothelial markers;…

In: Ultimate Heart

Tier 2

MicroActive® CoQ10 (24-hour sustained release)

CoQ10 RCTs/meta-analyses: improved endothelial function and reduced statin-associated muscle symptoms; MicroActive form shows universal…

In: Ultimate Heart

Tier 2

Nitrosigine® inositol-stabilized arginine silicate

Multiple RCTs at 1.5 g: raised plasma arginine/NO markers for 6 h; improved post-exercise cognitive flexibility; blood-flow and muscle-pump…

In: Ultimate Blood Flow · Ultimate Pre-Workout

Tier 2

OXYSTORM® red spinach extract (9% nitrate)

RCT (n=16): 2 g raised plasma/salivary nitrate-nitrite; 1 g raised calf blood flow at 30 min and delayed ventilatory threshold; 7–15-day…

In: Ultimate Blood Flow · Ultimate Pre-Workout · Forever Young

Tier 1

Pantesin® pantethine

28 trials (median 900 mg/day) lowered TC −8.7–15.1% and LDL −10–20%; triple-blind RCT at 600 mg/day: LDL −11% vs placebo in statin-eligible…

In: Ultimate Heart

Tier 1

Pycnogenol® French maritime pine bark extract

Randomized double-blind crossover (Enseleit, Eur Heart J): improved endothelial function in CAD patients at 200 mg; 100 mg/day improved FMD…

In: Ultimate Blood Flow

Tier 3

Rhamnan sulfate (Monostroma nitidum seaweed extract)

Glycocalyx-support ingredient; small human studies (microvascular perfusion, plaque imaging) sponsored by Calroy; mechanistic rationale…

In: Ultimate Blood Flow

Tier 2

Sytrinol® citrus PMFs + palm tocotrienols

Two open-label 4-wk pilots (n=10 each) and a 12-wk RCT (n=120) at 300 mg/day: TC −27% vs placebo; LDL and TG

In: Ultimate Heart

Tier 2

VINIA® red grape cell powder (piceid resveratrol)

Placebo-controlled 90-day trial: improved flow-mediated dilation and blood pressure (Vaisman 2015); acute FMD and PK

In: Ultimate Blood Flow · Ultimate Pre-Workout

Longevity & cellular health

Tier 4

5-Amino-1MQ (5-amino-1-methylquinolinium)

Rodent studies: NNMT inhibition reduced adipose mass and improved insulin sensitivity in diet-induced obesity, raised NAD+ and activated…

In: NNMT · 5-Amino-1MQ

Tier 3

ATX-304 (OS-01 · O-304 sodium salt, pan-AMPK activator)

Phase 2a RCT (n=65, T2D on metformin, 1,000 mg/day × 28 d): improved glucose handling, blood pressure and 6-min walk distance; 2026 phase…

In: AMPK Activator · ATX-304

Tier 3

Black ginger extract (Kaempferia parviflora, 5% methoxyflavones)

Small RCTs (100–150 mg/day): improved physical fitness/grip in older adults, hand-grip and NO markers; AMPK/SIRT activation

In: Ultimate Longevity

Tier 3

Calcium alpha-ketoglutarate (delayed-release)

Rejuvant retrospective (n=42): −8 yr TruAge after 7 mo; 2025 cross-sectional cohort (n=4,260) found delayed-release CaAKG the only compound…

In: Ultimate Longevity

Tier 3

Cyanidin-3-glucoside (black rice / bilberry, 25% C3G)

Anthocyanin RCTs (320 mg/day) improved HDL/LDL and endothelial markers; C3G-specific human data

In: Ultimate Longevity

Tier 3Liposomal

Fisetin (≥98%, liposomal)

Strong preclinical senolytic data; Mayo/PAD RCTs (FIRST, NCT06399809) ongoing; low-dose triple-blind RCT protocol published

In: Ultimate Longevity

Tier 3

GeneIII® L-ergothioneine (99.99%)

Independent RCT (n=147, 10/25 mg): primary memory endpoint null, secondary cognitive gains; MCI pilot (n=19, 25 mg 3×/wk); liver open-label…

In: Ultimate Longevity

Tier 2

Mitopure® urolithin A

ATLAS RCT (n=88, 500/1,000 mg × 4 mo): hamstring strength +12%/+9.8% vs placebo, primary endpoint (peak power) null; older-adult RCT (1,000…

In: Ultimate Longevity

Tier 3

pTeroPure® pterostilbene

Human RCT (125 mg b.i.d.): BP reduction; LDL increase at high dose (H-note); superior absorption vs

In: Ultimate Longevity

Tier 3

Quercefit® quercetin Phytosome™

PK superiority (20-fold); RCTs on exercise recovery/URTI symptoms at 250–500 mg; senolytic pairing with fisetin is

In: Ultimate Longevity

Tier 3

Spermidine-rich wheat germ extract (CelVio Complex®, 0.15% spermidine)

SmartAge RCT (n=100, 1.2 mg/day) improved memory performance trend; epidemiology links dietary spermidine with lower mortality; 2 mg/day =…

In: Ultimate Longevity

Tier 3

Telos95® (grapevine + olive leaf polyphenols)

6-month open study at 95 mg 1–2×/day reported telomere-length change; NO placebo arm (CSPI critique) — score

In: Ultimate Longevity

Tier 2

β-NMN (nicotinamide mononucleotide), NDIN-acknowledged source

Several RCTs (250–900 mg/day) raise blood NAD+; improved walking distance and insulin sensitivity in subsets; FDA Sept 29 2025 letters…

In: Ultimate Longevity

Brain & focus

Tier 4Liposomal

7,8-dihydroxyflavone (liposomal)

TrkB agonist with robust rodent data; no human

In: Ultimate Brain

Tier 2

AlphaSize® alpha-GPC

RCTs: 600 mg acute improved power output; 400–1,200 mg/day cognitive studies; Italian trials in cognitive

In: Ultimate Brain · Dopamine Boost

Tier 2

Bacognize® Bacopa monnieri

6-wk RCT in medical students (300 mg) improved memory/attention; 6-mo trial in geriatric cognitive decline; bacopa meta-analyses support…

In: Ultimate Brain

Tier 2

Cognizin® citicoline

28-day RCTs: improved attention in healthy women (250/500 mg) and adolescent males; 12-wk RCT in older adults improved episodic memory (500…

In: Ultimate Brain

Tier 3

enfinity® paraxanthine

Acute crossover RCT (n=13, 200 mg): improved attention, reaction time, memory vs placebo; dose-response 50/100/200 mg; 7-day safety

In: Focus Fuel

Tier 3

kollaJell™ hydrolyzed jellyfish collagen

Pilot RCT (n≈50) reported improved memory/processing scores at 150–300 mg (Prevagen-adjacent category); evidence

In: Ultimate Brain · Dopamine Boost

Tier 3

Lion's mane (Hericium erinaceus) fruiting body + mycelium 8:1, erinacine-A standardized

Five RCTs in systematic review: mild cognitive-impairment RCT (Mori 2009) positive; one null 12-wk RCT in adults >50 (LiverTox note);…

In: Ultimate Brain

Tier 2

Magtein® magnesium L-threonate

6-wk RCT (n=100, 2 g/day) improved cognition composite (p=0.043) and sleep; 21-day sleep RCT (n=80) at 1 g/day; 12-wk older-adult cognition…

In: Sleep & Recovery · Ultimate Minerals

Tier 3

Mucuna pruriens seed extract (15% L-DOPA)

Small RCTs: improved sperm parameters and stress hormones in infertile men; dopaminergic effects; Parkinson pilot data (high

In: Dopamine Boost

Tier 3

N-acetyl-L-tyrosine

Tyrosine (2 g) RCTs improve cognition under stress/sleep deprivation; NALT PK weaker than free tyrosine

In: Dopamine Boost

Tier 2

Rhodiolife® Rhodiola rosea (3% rosavins, 1% salidroside)

RCTs on fatigue, burnout symptoms and cognitive performance under stress (200–600 mg); Cochrane-level evidence

In: Dopamine Boost

Tier 2

Sharp-PS® GREEN sunflower phosphatidylserine

PS 100–300 mg/day RCTs: memory in age-associated memory impairment, attention in children (2025 RCT, 100 mg sunflower PS); FDA qualified…

In: Ultimate Brain

Tier 1

Vitamin B6 (pyridoxal-5′-phosphate)

Essential cofactor for dopamine decarboxylation; RDA-level

In: Dopamine Boost

Sleep & stress

Tier 3Liposomal

Apigenin (liposomal, ≥98%)

Human data mostly via chamomile extracts (sleep quality in older adults, GAD trials); isolated apigenin RCTs limited; liposomal form chosen…

In: Sleep & Recovery

Tier 2

Bifidobacterium longum 1714™ (ZenBiome™ strain)

RCTs: reduced perceived stress/cortisol; 2024 Sci Rep RCT improved sleep quality and

In: Sleep & Recovery · Gut Biome

Tier 2

Chamomile flower extract (1.2% apigenin)

RCTs: improved sleep quality in elderly and postpartum women; GAD trial at 1,500

In: Sleep & Recovery

Tier 2

Glycine

RCTs (3 g pre-bed) improved subjective sleep quality, next-day fatigue and core-temperature

In: Sleep & Recovery

Tier 3Liposomal

Honokiol (liposomal, 98% from Magnolia officinalis)

Magnolia-bark RCTs on stress/sleep (combinations); isolated honokiol data preclinical (NREM +35–48% in rodents); GABA-A positive

In: Sleep & Recovery

Tier 2

Lactium® (αS1-casein hydrolysate, α-casozepine)

RCTs at 150–300 mg: reduced stress markers and improved sleep in stressed

In: Sleep & Recovery

Tier 2

Levagen®+ palmitoylethanolamide (LipiSperse®)

Double-blind RCT (n=103, 350 mg × 8 wk): faster sleep onset and better actigraphy outcomes vs

In: Sleep & Recovery

Tier 1

Magnesium bisglycinate chelate (TRAACS®)

Magnesium RCTs improve sleep quality in older adults and insomnia; chelate form avoids

In: Sleep & Recovery · Ultimate Minerals

Tier 2

Suntheanine® L-theanine

Systematic review of 13 trials (n=550, 50–900 mg): improved sleep-related outcomes; alpha-wave and attention RCTs at 50–200

In: Focus Fuel · Sleep & Recovery

Microbiome

Tier 2

Akkermansia muciniphila WB-STR-001 (pasteurized)

RCT (n=32): pasteurized A. muciniphila 10^10/day × 3 mo improved insulin sensitivity and liver enzymes (Depommier 2019); Amansia weight…

In: Gut Biome

Tier 2

Aloe vera inner leaf 200:1 (acemannan ≥10%)

RCTs: IBS and GERD symptom reduction with inner-leaf

In: GI Repair

Tier 2

Bacillus subtilis HU58™ + B. coagulans (spore blend)

Spore-probiotic RCT (Bacillus blend) reduced post-prandial endotoxemia; B. coagulans IBS

In: Gut Biome

Tier 4

BPC-157 arginine salt (oral-stable)

Animal GI-protection and tendon data extensive; human RCTs absent; oral gut-targeted use described in the

In: GI Repair

Tier 3

CoreBiome® tributyrin

21-day RCT (n=32, 300 mg): microbiome shifts; in-vitro SHIME barrier/immune data

In: GI Repair

Tier 2

DGL licorice (deglycyrrhizinated, 4:1)

RCTs: dyspepsia/ulcer symptom

In: GI Repair

Tier 4

KPV tripeptide (Lys-Pro-Val)

Colitis models (oral KPV reduces inflammation via PepT1); no human

In: GI Repair

Tier 2

L-glutamine

RCTs: 5 g t.i.d. improved IBS-D with intestinal permeability; lower doses

In: GI Repair

Tier 1

Lacticaseibacillus rhamnosus GG (LGG®)

Most-studied strain (antibiotic-associated diarrhea, atopic

In: Gut Biome

Tier 2

Lactiplantibacillus plantarum PS128™

Psychobiotic RCTs (Tourette GI comorbidities 2026; athletes; mood); preclinical serotonin/dopamine

In: Gut Biome

Tier 3

Larazotide acetate (octapeptide)

Phase 2 RCTs in celiac disease reduced symptoms at 0.5 mg t.i.d.; phase 3 discontinued for futility

In: GI Repair

Tier 1

Limosilactobacillus reuteri DSM 17938

Dozens of RCTs (infant colic, H. pylori adjunct, bone density in older women

In: Gut Biome

Tier 5

Sodium bicarbonate (buffer)

Enteric buffer to protect peptides from gastric acid (formulation

In: GI Repair

Tier 1

Zinc L-carnosine (PepZin GI®)

RCTs: gastric mucosal protection, H. pylori adjunct (75 mg b.i.d.), NSAID gut injury, oral

In: GI Repair

Digestion & gut lining

Tier 2

2′-fucosyllactose + LNnT human-milk oligosaccharides (SuperHMO®)

RCTs in adults with IBS (2 g 2′-FL/LNnT × 4 wk) improved symptoms and

In: Gut Biome · Daily Digestion

Tier 2

Acacia (gum arabic) fiber

RCTs: bifidogenic, IBS symptom relief; very well

In: Daily Digestion

Tier 2

DigeZyme® multi-enzyme complex

RCT: reduced DOMS and improved recovery; digestive-comfort

In: Daily Digestion

Tier 1

Ginger root extract (5% gingerols)

Meta-analyses: nausea, gastric emptying,

In: Daily Digestion

Tier 3

Heat-killed Lactobacillus/Bifidobacterium postbiotic blend (e.g., L. paracasei MCC1849)

RCTs on immune markers and cold symptoms with heat-killed

In: Gut Biome

Tier 2

ImmunoLin® serum bovine immunoglobulin

Open-label and placebo-controlled trials (1.2–5 g) in IBS-D and HIV enteropathy; gut barrier

In: Daily Digestion

Tier 2Liposomal

Liposomal bovine colostrum (30% IgG)

RCTs: reduced exercise-induced intestinal permeability and URTI; IgG content

In: Daily Digestion

Tier 1

Sunfiber® partially hydrolyzed guar gum

RCTs: bowel regularity, IBS symptoms, sleep/motivation and cognition in elderly

In: Daily Digestion

Liver & detox

Tier 2

Acetyl-L-carnitine

RCTs/meta-analyses: depression adjunct, neuropathy, cognitive

In: Daily Detox

Tier 4

Calcium D-glucarate

β-glucuronidase inhibition; rodent data only, no human

In: Daily Detox

Tier 3

Gamma-glutamylcysteine (GGC)

Human PK: raised lymphocyte glutathione within hours; small trials

In: Daily Detox

Tier 2

Milk thistle (Siliphos® silybin phytosome)

Siliphos RCTs in NAFLD/ hepatitis improved enzymes; phytosome PK

In: Daily Detox

Tier 1

N-acetyl-L-cysteine (NAC)

Decades of RCTs (glutathione precursor, mucolytic, psychiatric

In: Daily Detox

Tier 3

N-acetyl-L-cysteine ethyl ester (NACET)

Lipophilic NAC prodrug with far higher oral bioavailability (PubMed 23000913); human RCTs absent

In: Daily Detox

Tier 2

Olive leaf extract (20% oleuropein + hydroxytyrosol)

RCTs: BP reduction (500 mg b.i.d. vs captopril), insulin sensitivity; hydroxytyrosol EFSA

In: Daily Detox

Tier 2

Phosphatidylcholine (sunflower, ≥50%)

Essential-phospholipid trials in fatty liver and liver enzymes

In: Daily Detox

Tier 2

Setria® L-glutathione (reduced)

6-mo RCT (n=54): oral GSH 250/1,000 mg raised body stores and NK

In: Daily Detox

Tier 2

Stabilized R-lipoic acid (Na-R-ALA)

ALA RCTs: neuropathy symptoms, insulin sensitivity; R-form PK

In: Daily Detox

Tier 2

Stabilized sulforaphane complex (broccoli seed glucoraphanin + active myrosinase)

Sulforaphane RCTs: detox enzyme induction, autism behavior, H. pylori, airway inflammation (10–40

In: Daily Detox

Tier 3

TUDCA (tauroursodeoxycholic acid)

Human trials in cholestasis/liver enzymes (500–1,500 mg) and insulin sensitivity (1,750 mg); supplement-dose RCTs

In: Daily Detox

Muscle & performance

Tier 3Standalone candidate

6′-sialyllactose (6′-SL) HMO

12-wk RCT (900 mg) in trained men was NULL for strength/lean mass; GNE-myopathy pilots at 3–6 g; preclinical muscle

Tier 2

Cluster Dextrin® highly branched cyclic dextrin

RCTs: lower RPE and faster gastric emptying vs maltodextrin; 30 g CrossFit acute trial; 2025 crossover

In: Ultimate Intra-Workout

Tier 1

Creapure® creatine monohydrate

Hundreds of RCTs/meta-analyses: strength, lean mass, cognition under sleep deprivation; ISSN position

In: Ultimate Morning · Muscle & Strength

Tier 3

Creatine hydrochloride

Higher solubility; small RCTs show comparable lean-mass gains to monohydrate at lower

In: Muscle & Strength

Tier 1

Electrolyte complex (sodium 300 mg, potassium 200 mg, magnesium 50 mg from Aquamin® Mg, chloride)

Hydration/performance RCTs; sodium-containing beverages maintain plasma

In: Ultimate Morning · Ultimate Pre-Workout · Ultimate Intra-Workout

Tier 1

Essential amino acids (fermentation, leucine-enriched 40%)

EAA 6–10 g RCTs stimulate MPS comparably to 20–25 g protein; intra-workout EAA

In: Ultimate Intra-Workout

Tier 1

Grass-fed whey protein isolate (cold-processed, non-denatured)

Gold-standard protein for MPS; hundreds of

In: Grass-Fed Whey Isolate

Tier 2

Guanidinoacetic acid (GAA)

RCTs: GAA 1.2–3 g raises muscle and brain creatine more than creatine; homocysteine rise mitigated by TMG/B

In: Muscle & Strength

Tier 1

L-citrulline (fermentation)

Meta-analyses: 6–8 g improves high-intensity performance and reduces soreness; raises plasma arginine more than

In: Ultimate Pre-Workout

Tier 2

L-ornithine α-ketoglutarate (OKG)

Clinical-nutrition RCTs (burns, surgery) on nitrogen balance; ornithine reduces ammonia/fatigue in exercise

In: Ultimate Pre-Workout

Tier 2

LactoSpore® Bacillus coagulans MTCC 5856

RCT: improved protein absorption with whey; IBS symptom

In: Grass-Fed Whey Isolate

Tier 2

Mediator® phosphatidic acid (soy, 50%)

8-wk RCT (n=28): PA 750 mg + resistance training increased lean mass and strength vs placebo; replication mixed

In: Muscle & Strength

Tier 2

PeakATP® (adenosine 5′-triphosphate disodium)

RCTs: 400 mg acute improved lower-body resistance performance; 2-wk 3MT study; 12-wk lean-mass/strength

In: Ultimate Pre-Workout

Tier 2

PeptiStrong® fava bean protein hydrolysate

3 RCTs at 2.4 g/day: strength +17–20%, improved recovery from disuse, bone-density signal in 56

In: Muscle & Strength · Grass-Fed Whey Isolate

Tier 2

ProHydrolase® protease blend

RCT: increased amino-acid absorption from whey, reduced large-peptide

In: Grass-Fed Whey Isolate

Joints, skin & recovery

Tier 2

FORTIBONE® bioactive collagen peptides

12-mo RCT (n=131 postmenopausal women): 5 g/day raised lumbar and femoral-neck BMD T-scores vs

In: Ultimate Recovery

Tier 1

FORTIGEL® bioactive collagen peptides

24-wk RCT (n=139 athletes) and 12-wk RCT (n=182): 5 g/day reduced activity-related knee/hip

In: Ultimate Recovery

Tier 2

Hyaluronic acid (HyaCera™, low molecular weight)

RCTs: skin hydration (120 mg) and knee OA symptoms (oral

In: Ultimate Recovery

Tier 2

TENDOFORTE® bioactive collagen peptides

RCTs: 5 g/day improved Achilles tendinopathy outcomes and ankle stability in

In: Ultimate Recovery

Tier 1

UC-II® undenatured type II collagen

Multiple RCTs (40 mg/day): knee flexibility and joint comfort in healthy adults and OA (superior to

In: Ultimate Recovery

Tier 2

VERISOL® bioactive collagen peptides

RCTs (2.5 g × 8 wk): skin elasticity, wrinkles, cellulite,

In: Ultimate Recovery

Vitality — Barlowe's Herbal Elixirs

Tier 3

Catuaba bark 10:1 extract (Barlowe's)

Traditional Brazilian aphrodisiac; preclinical dopaminergic/antidepressant data; human RCTs

In: Forever Young

Tier 3

Cistanche deserticola 10:1 extract (Barlowe's)

RCTs in China on memory and fatigue; TCM "desert ginseng"; androgen-support

In: Forever Young

Tier 3

Mondia whitei tuber 5:1 extract (Barlowe's)

Traditional African libido/sperm-motility herb; in-vitro sperm motility data; small human study

In: Forever Young

Tier 3

Mpesu root powder (Securidaca longepedunculata, Barlowe's)

Traditional southern-African male-vitality herb; ethnobotanical and preclinical data

In: Forever Young

Peptide bioregulators

Tier 3

Bonomarlot® (A-20) natural bone marrow peptide complex

Khavinson bioregulator literature: open and controlled Russian trials on bone marrow-system function with cytomax peptides; hematopoietic…

In: BioRegulate Musculoskeletal

Tier 3

Cerluten® (A-5) natural brain cortex peptide complex

Khavinson bioregulator literature: open and controlled Russian trials on brain cortex-system function with cytomax peptides;…

In: BioRegulate Neuro

Tier 3

Chelohart® (A-14) natural heart muscle peptide complex

Khavinson bioregulator literature: open and controlled Russian trials on heart muscle-system function with cytomax peptides; cardiac…

In: BioRegulate Cardio

Tier 3

Endoluten® (A-8) natural pineal gland peptide complex

Khavinson bioregulator literature: open and controlled Russian trials on pineal gland-system function with cytomax peptides; melatonin…

In: BioRegulate Neuro · BioRegulate Immune-Endocrine · BioRegulate Female Vitality

Tier 3

Glandokort® (A-17) natural adrenal peptide complex

Khavinson bioregulator literature: open and controlled Russian trials on adrenal-system function with cytomax peptides; stress-axis…

In: BioRegulate Immune-Endocrine · BioRegulate Male Vitality

Tier 3

Gotratix® (A-18) natural skeletal muscle peptide complex

Khavinson bioregulator literature: open and controlled Russian trials on skeletal muscle-system function with cytomax peptides;…

In: BioRegulate Musculoskeletal

Tier 3

Libidon® (A-16) natural prostate peptide complex

Khavinson bioregulator literature: open and controlled Russian trials on prostate-system function with cytomax peptides; prostate-function…

In: BioRegulate Male Vitality

Tier 3Standalone candidate

NexGen BioShield™ delivery matrix (sunflower phospholipid liposome + acid-resistant DRcaps®)

DRcaps dissolution data (delayed gastric release); liposomal peptide-protection rationale; the "novel bioavailable formulation"

Tier 2

R-alpha-lipoic acid (bioregulator cofactor)

BioMale-style cofactor; ALA RCT

In: BioRegulate Neuro · BioRegulate Cardio · BioRegulate Immune-Endocrine · BioRegulate Male Vitality · BioRegulate Female Vitality · BioRegulate Musculoskeletal

Tier 3

Sigumir® (A-4) natural cartilage peptide complex

Khavinson bioregulator literature: open and controlled Russian trials on cartilage-system function with cytomax peptides; joint-function…

In: BioRegulate Musculoskeletal

Tier 3

Svetinorm® (A-7) natural liver peptide complex

Khavinson bioregulator literature: open and controlled Russian trials on liver-system function with cytomax peptides; hepatic function…

In: BioRegulate Cardio

Tier 3

Testoluten® (A-13) natural testes peptide complex

Khavinson bioregulator literature: open and controlled Russian trials on testes-system function with cytomax peptides; spermatogenesis and…

In: BioRegulate Male Vitality

Tier 3

Thyreogen® (A-2) natural thyroid peptide complex

Khavinson bioregulator literature: open and controlled Russian trials on thyroid-system function with cytomax peptides; thyroid-function…

In: BioRegulate Immune-Endocrine · BioRegulate Female Vitality

Tier 3

Ventfort® (A-3) natural blood vessel peptide complex

Khavinson bioregulator literature: open and controlled Russian trials on blood vessel-system function with cytomax peptides; vascular…

In: BioRegulate Neuro · BioRegulate Cardio · BioRegulate Male Vitality · BioRegulate Female Vitality · BioRegulate Musculoskeletal

Tier 3

Vladonix® (A-6) natural thymus peptide complex

Khavinson bioregulator literature: open and controlled Russian trials on thymus-system function with cytomax peptides; immune-aging…

In: BioRegulate Immune-Endocrine

Tier 3

Zhenoluten® (A-15) natural ovary peptide complex

Khavinson bioregulator literature: open and controlled Russian trials on ovary-system function with cytomax peptides; female…

In: BioRegulate Female Vitality

Standalone candidates (not yet in a formula)

Tier 1Standalone candidate

Aged garlic extract (Kyolic®)

RCTs: BP and coronary calcium progression

Tier 2Standalone candidate

AHCC® (Amino Up)

RCT/open trials: HPV clearance, NK activity; 3

Tier 4Standalone candidate

C60 fullerene in olive oil

Rat lifespan study (Baati 2012) never replicated; no human

Tier 1Standalone candidate

Dihydroberberine (GlucoVantage®)

Berberine meta-analyses (HbA1c, lipids); DHB PK 5× — but user irritant rule: standalone

Tier 1Standalone candidate

Herbatonin® plant melatonin

Melatonin meta-analyses for sleep onset/jet lag; plant-derived

Tier 3Standalone candidate

Lithium orotate (micro-dose)

Epidemiology on trace lithium and mortality/dementia; low-dose RCTs small — offered standalone

Tier 2Standalone candidate

PectaSol® modified citrus pectin

RCTs: galectin-3, PSA doubling time, heavy-metal excretion

Tier 3Standalone candidate

Systemic enzymes (serrapeptase + nattokinase)

Nattokinase RCTs (BP, fibrinolysis); serrapeptase

These statements have not been evaluated by the Food and Drug Administration. These products are not intended to diagnose, treat, cure or prevent any disease. Nothing on this site is medical advice — it is educational "what I would do if I were you" guidance from an executive health coach. Talk with your clinician before starting any supplement, especially if you take medication, are pregnant or nursing, or have a medical condition. *Formulations are unofficial — Version 2.0 specifications are being finalized ahead of the first single-batch run and may change before release. Supplement Facts shown are the current design targets, not a finished label.

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