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On this page
Evidence Form & dose Cautions In our formulas FAQ Sources
Tier 3 · mechanistic / traditional / early human Liposomal / enhanced delivery
Fisetin (≥98%, liposomal)
Strong preclinical senolytic data; Mayo/PAD RCTs (FIRST, NCT06399809) ongoing; low-dose triple-blind RCT protocol published 2026.
5 /10 evidence score
100 mg studied dose used
What the evidence shows Strong preclinical senolytic data; Mayo/PAD RCTs (FIRST, NCT06399809) ongoing; low-dose triple-blind RCT protocol published 2026.
Tier is our appraisal of the human evidence at the dose we use: Tier 1 = multiple randomized trials; Tier 2 = human trials, fewer or smaller; Tier 3 = mechanistic, traditional or early human data; Tier 4 = emerging. Ingredients below Tier 2 are included only where the safety record is long and the traditional use is specific.
Who should be careful Low oral bioavailability (liposomal form chosen); none significant. Talk with your clinician before starting if any of this applies to you.
FAQ Which NEX-GEN formulas contain Fisetin (≥98%, liposomal)? Ultimate Longevity (100 mg per serving). Every formula lists its full dose on the Supplement Facts panel — no proprietary blends.
What form of Fisetin does NEX-GEN use and why? Fisetin from Rhus succedanea. We choose the most bioavailable form we can source at the studied dose. Liposomal delivery is used here.
What does the evidence actually show for Fisetin? Strong preclinical senolytic data; Mayo/PAD RCTs (FIRST, NCT06399809) ongoing; low-dose triple-blind RCT protocol published 2026.
Who should be careful with it? Low oral bioavailability (liposomal form chosen); none significant. Talk with your clinician before starting if any of this applies to you.
These statements have not been evaluated by the Food and Drug Administration. These products are not intended to diagnose, treat, cure or prevent any disease. Nothing on this site is medical advice — it is educational "what I would do if I were you" guidance from an executive health coach. Talk with your clinician before starting any supplement, especially if you take medication, are pregnant or nursing, or have a medical condition. Last reviewed October 2026.
