Version 2.0 formulas releasing soon · Single batch every time — every batch reformulated and matched to the latest scientific evidence · 166 evidence-based compounds across 30 products.Version 2.0 releasing soon · Single batch every time · 166 compounds across 30 products.
Formulas built the way I would build them for myself.
Tier 3 · mechanistic / traditional / early human
Calcium alpha-ketoglutarate (delayed-release)
Rejuvant retrospective (n=42): −8 yr TruAge after 7 mo; 2025 cross-sectional cohort (n=4,260) found delayed-release CaAKG the only compound of 84 associated with lower biological age. No RCT on hard endpoints.
5/10evidence score
500 mgstudied dose used
What the evidence shows
Rejuvant retrospective (n=42): −8 yr TruAge after 7 mo; 2025 cross-sectional cohort (n=4,260) found delayed-release CaAKG the only compound of 84 associated with lower biological age. No RCT on hard endpoints.
Tier is our appraisal of the human evidence at the dose we use: Tier 1 = multiple randomized trials; Tier 2 = human trials, fewer or smaller; Tier 3 = mechanistic, traditional or early human data; Tier 4 = emerging. Ingredients below Tier 2 are included only where the safety record is long and the traditional use is specific.
Form and dose
Form used
Ca-AKG ≥98%
Dose per serving
500 mg
Delivery
Standard / as studied
Who should be careful
Well tolerated; calcium load ~100 mg. Talk with your clinician before starting if any of this applies to you.
Which NEX-GEN formulas contain Calcium alpha-ketoglutarate (delayed-release)?
Ultimate Longevity (500 mg per serving). Every formula lists its full dose on the Supplement Facts panel — no proprietary blends.
What form of Calcium alpha-ketoglutarate does NEX-GEN use and why?
Ca-AKG ≥98%. We choose the most bioavailable form we can source at the studied dose.
What does the evidence actually show for Calcium alpha-ketoglutarate?
Rejuvant retrospective (n=42): −8 yr TruAge after 7 mo; 2025 cross-sectional cohort (n=4,260) found delayed-release CaAKG the only compound of 84 associated with lower biological age. No RCT on hard endpoints.
Who should be careful with it?
Well tolerated; calcium load ~100 mg. Talk with your clinician before starting if any of this applies to you.
These statements have not been evaluated by the Food and Drug Administration. These products are not intended to diagnose, treat, cure or prevent any disease. Nothing on this site is medical advice — it is educational "what I would do if I were you" guidance from an executive health coach. Talk with your clinician before starting any supplement, especially if you take medication, are pregnant or nursing, or have a medical condition. Last reviewed October 2026.
The protocols we cannot publish here
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