Formulas built the way I would build them for myself.
Version 2.0Single-batch runChangelog
NAD+ · mitophagy · senolytic · telomere support
The eleven longevity actives Jason takes every morning — NDIN-sourced NMN, Mitopure®, spermidine, Ca-AKG, liposomal fisetin, Quercefit® and GeneIII® ergothioneine.
$249 $212/mo on subscription · from $187/unit on a 3-pack subscription
No payment is collected today — pre-orders are saved to your list and confirmed by email. Checkout opens January 1, 2027. How pricing works.
No proprietary blends. Each line below is on the Supplement Facts panel at exactly this amount. Tier is our appraisal of the human evidence; sources are linked.
Evidence. Several RCTs (250–900 mg/day) raise blood NAD+; improved walking distance and insulin sensitivity in subsets; FDA Sept 29 2025 letters declare NMN not excluded from the supplement definition.
Cautions. Flushing rare; long-term outcome data absent.
nutraingredients.com/Article/2025/09/30/f…venable.com/insights/publications/2025/10…nutraingredients.com/Article/2025/12/09/f…
Evidence. ATLAS RCT (n=88, 500/1,000 mg × 4 mo): hamstring strength +12%/+9.8% vs placebo, primary endpoint (peak power) null; older-adult RCT (1,000 mg) improved muscle endurance, 6MWT primary null.
Cautions. Well tolerated; null primary endpoints noted.
pmc.ncbi.nlm.nih.gov/articles/PMC9133463/jamanetwork.com/journals/jamanetworkopen/…
Evidence. SmartAge RCT (n=100, 1.2 mg/day) improved memory performance trend; epidemiology links dietary spermidine with lower mortality; 2 mg/day = 1,300 mg extract.
Cautions. Contains wheat (gluten) — label allergen.
spermidinelife.com/en/products/spermidine…pubmed.ncbi.nlm.nih.gov/?term=spermidine+…
Evidence. Rejuvant retrospective (n=42): −8 yr TruAge after 7 mo; 2025 cross-sectional cohort (n=4,260) found delayed-release CaAKG the only compound of 84 associated with lower biological age. No RCT on hard endpoints.
Cautions. Well tolerated; calcium load ~100 mg.
pmc.ncbi.nlm.nih.gov/articles/PMC8660611/onlinelibrary.wiley.com/doi/10.1111/acel.70517
Evidence. Strong preclinical senolytic data; Mayo/PAD RCTs (FIRST, NCT06399809) ongoing; low-dose triple-blind RCT protocol published 2026.
Cautions. Low oral bioavailability (liposomal form chosen); none significant.
clinicaltrials.gov/study/NCT06399809pubmed.ncbi.nlm.nih.gov/42633989/
Evidence. PK superiority (20-fold); RCTs on exercise recovery/URTI symptoms at 250–500 mg; senolytic pairing with fisetin is preclinical.
Cautions. CYP3A4/P-gp interaction potential at high doses.
Evidence. Independent RCT (n=147, 10/25 mg): primary memory endpoint null, secondary cognitive gains; MCI pilot (n=19, 25 mg 3×/wk); liver open-label at 60 mg.
Cautions. Well tolerated; primary endpoint null noted.
geneiii.com/products/l-ergothioneine-capsulespubmed.ncbi.nlm.nih.gov/39544014/
Evidence. 6-month open study at 95 mg 1–2×/day reported telomere-length change; NO placebo arm (CSPI critique) — score capped.
Cautions. None reported; evidence quality flag (H-note: no placebo).
certifiednutra.com/ingredient-solutions/t…cspi.org/daily/dietary-supplements/what-d…
Evidence. Anthocyanin RCTs (320 mg/day) improved HDL/LDL and endothelial markers; C3G-specific human data limited.
Cautions. None significant.
Evidence. Small RCTs (100–150 mg/day): improved physical fitness/grip in older adults, hand-grip and NO markers; AMPK/SIRT activation preclinical.
Cautions. None significant.
Evidence. Human RCT (125 mg b.i.d.): BP reduction; LDL increase at high dose (H-note); superior absorption vs resveratrol.
Cautions. Raised LDL at 250 mg/day in one RCT — kept to 50 mg.
api.ods.od.nih.gov/dsld/s3/pdf/181999.pdfpubmed.ncbi.nlm.nih.gov/?term=pterostilbe…
Serving size 4 capsules
Servings per container 30
| Amount per serving | % DV | |
|---|---|---|
| β-NMN (nicotinamide mononucleotide), NDIN-acknowledged source | 500 mg | † |
| Mitopure® urolithin A | 500 mg | † |
| Spermidine-rich wheat germ extract (CelVio Complex®, 0.15% spermidine) | 650 mg | † |
| Calcium alpha-ketoglutarate (delayed-release) | 500 mg | † |
| Fisetin (≥98%, liposomal) | 100 mg | † |
| Quercefit® quercetin Phytosome™ | 250 mg | † |
| GeneIII® L-ergothioneine (99.99%) | 30 mg | † |
| Telos95® (grapevine + olive leaf polyphenols) | 95 mg | † |
| Cyanidin-3-glucoside (black rice / bilberry, 25% C3G) | 100 mg | † |
| Black ginger extract (Kaempferia parviflora, 5% methoxyflavones) | 100 mg | † |
| pTeroPure® pterostilbene | 50 mg | † |
† Daily Value not established. Percent Daily Values are based on a 2,000-calorie diet.
Other ingredients: plant-based capsule (pullulan), sunflower lecithin (liposomal carrier), rice hull concentrate.
Directions: Take 4 capsules in the morning on an empty stomach with water. Fisetin + Quercefit® may be pulsed (e.g., 3 days per month at double dose) under coaching guidance.
*Formulations are unofficial — Version 2.0 specifications are being finalized ahead of the first single-batch run and may change before release. Supplement Facts shown are the current design targets, not a finished label.
Matte black label on amber glass with metallic blue edges. Final artwork is proofed before the first run.
| One-time | |
| Subscribe monthly | $212 |
| 3-pack | $199/unit |
| 3-pack subscription | $187/unit |
Stack it with up to four other formulas for 5–25% more off every rung. Build a stack →
Buy a 3-pack (one-time or subscription), complete four short surveys over 90 days, and earn back 25% of what you paid as store credit — or 40% as subscription credit. Self-reported, published in aggregate, never called a clinical trial.
How it worksVersion 2.0 is made once. When this batch sells out it is gone; the next version is announced before it is made. If this formula is working for you, tell us to keep it — and buy a few extra bottles just in case.
Read the changelogFDA's September 2025 letters confirmed NMN is lawful as a dietary ingredient; we source only from suppliers with an acknowledged NDI notification. NMN is the form Jason uses, and the human trial base is now comparable to NR.
That delivers ~1 mg spermidine — half the SmartAge trial dose — because the 4-capsule limit is binding. The Morning powder does not duplicate it; take 8 capsules per day if you want the full 2 mg (open decision).
Every NEX-GEN formula starts at Version 2.0 and later versions may be announced each quarter. Each run is a single batch — once it sells out, that exact version is retired. If you love a version, tell us to keep it, and buy a few extra bottles just in case.
Pre-order adds the item to your saved cart and emails a confirmation that your bottles are reserved. No payment is taken now; you will be prompted to complete checkout when the Version 2.0 batch releases in early 2027.
Version 2.0 ships early 2027 in the order pre-orders were placed. Pre-orders open January 1, 2027; until then you can save it to your list at no cost.
These statements have not been evaluated by the Food and Drug Administration. These products are not intended to diagnose, treat, cure or prevent any disease. Nothing on this site is medical advice — it is educational "what I would do if I were you" guidance from an executive health coach. Talk with your clinician before starting any supplement, especially if you take medication, are pregnant or nursing, or have a medical condition.
Methylated Bs · liposomal C · cocoa flavanols · electrolytes · fulvic
$99 $84/mo on subscription · from $74/unit on a 3-pack subscription
D3 · A · K1/K2 · tocotrienol E · astaxanthin · lutein · saffron · LPC-omega-3
$129 $110/mo on subscription · from $97/unit on a 3-pack subscription
7-form magnesium · fulvic/humic · full trace spectrum
$69 $59/mo on subscription · from $52/unit on a 3-pack subscription
A one-hour, one-on-one session with Jason Johns that ends with your own customized edition of The Ultimate Handbook of Health: detailed, personalized protocols including peptides, bioregulators, and highly specific supplement timing and an interactions checker — a stack designed for your biology and taken when it can actually be absorbed.
