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Several RCTs (250–900 mg/day) raise blood NAD+; improved walking distance and insulin sensitivity in subsets; FDA Sept 29 2025 letters declare NMN not excluded from the supplement definition.
7/10evidence score
SyncoZymes / Kingdomwaylicensed form owner
500 mgstudied dose used
What the evidence shows
Several RCTs (250–900 mg/day) raise blood NAD+; improved walking distance and insulin sensitivity in subsets; FDA Sept 29 2025 letters declare NMN not excluded from the supplement definition.
Tier is our appraisal of the human evidence at the dose we use: Tier 1 = multiple randomized trials; Tier 2 = human trials, fewer or smaller; Tier 3 = mechanistic, traditional or early human data; Tier 4 = emerging. Ingredients below Tier 2 are included only where the safety record is long and the traditional use is specific.
Form and dose
Form used
≥99% β-NMN
Branded source
SyncoZymes / Kingdomway
Dose per serving
500 mg
Delivery
Standard / as studied
Who should be careful
Flushing rare; long-term outcome data absent. Talk with your clinician before starting if any of this applies to you.
Which NEX-GEN formulas contain β-NMN (nicotinamide mononucleotide), NDIN-acknowledged source?
Ultimate Longevity (500 mg per serving). Every formula lists its full dose on the Supplement Facts panel — no proprietary blends.
What form of β-NMN does NEX-GEN use and why?
≥99% β-NMN. We use the licensed branded form so the dose on our label matches the material studied in the trials.
What does the evidence actually show for β-NMN?
Several RCTs (250–900 mg/day) raise blood NAD+; improved walking distance and insulin sensitivity in subsets; FDA Sept 29 2025 letters declare NMN not excluded from the supplement definition.
Who should be careful with it?
Flushing rare; long-term outcome data absent. Talk with your clinician before starting if any of this applies to you.
These statements have not been evaluated by the Food and Drug Administration. These products are not intended to diagnose, treat, cure or prevent any disease. Nothing on this site is medical advice — it is educational "what I would do if I were you" guidance from an executive health coach. Talk with your clinician before starting any supplement, especially if you take medication, are pregnant or nursing, or have a medical condition. Last reviewed October 2026.
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