Betaine anhydrous (TMG)
RCTs: 2.5 g/day improved body composition and power in trained men; lowers homocysteine (pairs with
In: Ultimate Morning

Formulas built the way I would build them for myself.
166 ingredients across the Version 2.0 line — branded form, studied dose, what the human trials show, who should be careful, and which formula it sits in.
RCTs: 2.5 g/day improved body composition and power in trained men; lowers homocysteine (pairs with
In: Ultimate Morning
Essential nutrient; AI 550 mg/day
In: Ultimate Morning
COSMOS RCT (n=21,442): cocoa extract 500 mg flavanols/day reduced CVD death 27%; FMD and BP
In: Ultimate Morning
RCTs: fatigue/fibromyalgia symptom and exercise recovery; heart-failure diastolic
In: Ultimate Morning
Mineral repletion rationale; limited
In: Ultimate Morning
PureWay-C PK: faster uptake and retention vs ascorbic acid; vitamin C essential for collagen
In: Ultimate Morning · Ultimate Recovery
Essential; active forms bypass MTHFR/conversion; Quatrefolic PK superior to folic
In: Ultimate Morning
RCTs: reduced inflammation markers and fatigue in athletes; metabolic syndrome trial
Meta-analyses: BP, lipids, exercise performance; longevity signal in animals (2023
In: Ultimate Morning
RCTs: skin photoprotection (4–12 mg), eye fatigue, exercise
In: D·A·K·E
AREDS2 and LAMA trials: macular pigment, visual
In: D·A·K·E
Mfsd2a-transport rationale for brain DHA; human PK studies; outcome RCTs
In: D·A·K·E
RCTs at 28 mg: mood, sleep; saffron for eye health at 20–30
In: D·A·K·E
Essential; pairs with D for receptor
In: D·A·K·E
Deficiency correction RCTs; 5,000 IU/day typical for serum 50–80
In: D·A·K·E
Essential;
In: D·A·K·E
Japanese osteoporosis trials used 45 mg; low-dose MK-4 raises carboxylated
In: D·A·K·E
3-yr RCT (n=244): 180 mcg/day improved arterial stiffness and bone strength (Knapen
In: D·A·K·E
Bioavailability study (PubMed 30018220) shows good Mg retention; trace-mineral
In: Ultimate Minerals
RCTs at 3–10 mg: raised free testosterone, lowered SHBG and hs-CRP in men; bone/joint
In: Ultimate Minerals
Meta-analyses: modest glycemic benefit in
In: Ultimate Minerals
Essential; balances
In: Ultimate Minerals
Narrative reviews and 2025 safety/microbiota profiling; human trials sparse (NCT07579845 pending on epigenetic
In: Ultimate Minerals · Ultimate Morning
Essential; RDA 150
In: Ultimate Minerals
Raised brain Mg in rodents (PubMed 30761462); taurine co-benefit; human RCTs
In: Ultimate Minerals
Highly bioavailable; multiple RCTs (BP,
In: Ultimate Minerals
Fibromyalgia pilot RCTs; malate feeds the Krebs cycle; good
In: Ultimate Minerals
Heart-failure RCT (Stepura 2009) improved survival/symptoms at 6 g/day; small doses
In: Ultimate Minerals
Essential cofactor
In: Ultimate Minerals
Essential cofactor (sulfite
In: Ultimate Minerals
RCTs: 250/500 mg × 8 wk maintained strength after fatigue; 90-day trial raised total testosterone in healthy men (n=75); mitochondrial…
In: Ultimate Minerals
Essential; thyroid/antioxidant
In: Ultimate Minerals
Essential; RCTs on immune/testosterone status in
In: Ultimate Minerals
Artichoke leaf extract meta-analyses show modest LDL/TG reduction; ginger lowers TG in small RCTs. Combination data limited to the branded…
In: Ultimate Heart
11 published human trials; 237-pt RCT at 500/1,000 mg × 30 d improved total/LDL cholesterol, TG and glucose vs placebo; 77-pt trial with…
In: Ultimate Heart
50+ years of trials; FDA-authorized health claim at ≥0.8 g/day plant sterols for reduced CHD risk; LDL −8–10% at 2
In: Ultimate Heart
Sea buckthorn proanthocyanidins: biomarker trials on vascular and skin outcomes; limited branded human
In: Ultimate Blood Flow
250 mg/day δ-tocotrienol improved lipid and inflammatory markers in several small RCTs (n≈31–60); 14-day crossover raised plasma δ-T3 and…
In: Ultimate Heart · D·A·K·E
Human pilot data on statin-associated muscle symptoms and testosterone support in men on statins; mechanistic rationale (mevalonate…
In: Ultimate Heart · D·A·K·E
RCT in 60 treated hypertensives: standardized tomato extract (15 mg lycopene) lowered systolic BP and improved endothelial markers;…
In: Ultimate Heart
CoQ10 RCTs/meta-analyses: improved endothelial function and reduced statin-associated muscle symptoms; MicroActive form shows universal…
In: Ultimate Heart
Multiple RCTs at 1.5 g: raised plasma arginine/NO markers for 6 h; improved post-exercise cognitive flexibility; blood-flow and muscle-pump…
In: Ultimate Blood Flow · Ultimate Pre-Workout
RCT (n=16): 2 g raised plasma/salivary nitrate-nitrite; 1 g raised calf blood flow at 30 min and delayed ventilatory threshold; 7–15-day…
In: Ultimate Blood Flow · Ultimate Pre-Workout · Forever Young
28 trials (median 900 mg/day) lowered TC −8.7–15.1% and LDL −10–20%; triple-blind RCT at 600 mg/day: LDL −11% vs placebo in statin-eligible…
In: Ultimate Heart
Randomized double-blind crossover (Enseleit, Eur Heart J): improved endothelial function in CAD patients at 200 mg; 100 mg/day improved FMD…
In: Ultimate Blood Flow
Glycocalyx-support ingredient; small human studies (microvascular perfusion, plaque imaging) sponsored by Calroy; mechanistic rationale…
In: Ultimate Blood Flow
Two open-label 4-wk pilots (n=10 each) and a 12-wk RCT (n=120) at 300 mg/day: TC −27% vs placebo; LDL and TG
In: Ultimate Heart
Placebo-controlled 90-day trial: improved flow-mediated dilation and blood pressure (Vaisman 2015); acute FMD and PK
In: Ultimate Blood Flow · Ultimate Pre-Workout
Rodent studies: NNMT inhibition reduced adipose mass and improved insulin sensitivity in diet-induced obesity, raised NAD+ and activated…
In: NNMT · 5-Amino-1MQ
Phase 2a RCT (n=65, T2D on metformin, 1,000 mg/day × 28 d): improved glucose handling, blood pressure and 6-min walk distance; 2026 phase…
In: AMPK Activator · ATX-304
Small RCTs (100–150 mg/day): improved physical fitness/grip in older adults, hand-grip and NO markers; AMPK/SIRT activation
In: Ultimate Longevity
Rejuvant retrospective (n=42): −8 yr TruAge after 7 mo; 2025 cross-sectional cohort (n=4,260) found delayed-release CaAKG the only compound…
In: Ultimate Longevity
Anthocyanin RCTs (320 mg/day) improved HDL/LDL and endothelial markers; C3G-specific human data
In: Ultimate Longevity
Strong preclinical senolytic data; Mayo/PAD RCTs (FIRST, NCT06399809) ongoing; low-dose triple-blind RCT protocol published
In: Ultimate Longevity
Independent RCT (n=147, 10/25 mg): primary memory endpoint null, secondary cognitive gains; MCI pilot (n=19, 25 mg 3×/wk); liver open-label…
In: Ultimate Longevity
ATLAS RCT (n=88, 500/1,000 mg × 4 mo): hamstring strength +12%/+9.8% vs placebo, primary endpoint (peak power) null; older-adult RCT (1,000…
In: Ultimate Longevity
Human RCT (125 mg b.i.d.): BP reduction; LDL increase at high dose (H-note); superior absorption vs
In: Ultimate Longevity
PK superiority (20-fold); RCTs on exercise recovery/URTI symptoms at 250–500 mg; senolytic pairing with fisetin is
In: Ultimate Longevity
SmartAge RCT (n=100, 1.2 mg/day) improved memory performance trend; epidemiology links dietary spermidine with lower mortality; 2 mg/day =…
In: Ultimate Longevity
6-month open study at 95 mg 1–2×/day reported telomere-length change; NO placebo arm (CSPI critique) — score
In: Ultimate Longevity
Several RCTs (250–900 mg/day) raise blood NAD+; improved walking distance and insulin sensitivity in subsets; FDA Sept 29 2025 letters…
In: Ultimate Longevity
TrkB agonist with robust rodent data; no human
In: Ultimate Brain
RCTs: 600 mg acute improved power output; 400–1,200 mg/day cognitive studies; Italian trials in cognitive
In: Ultimate Brain · Dopamine Boost
6-wk RCT in medical students (300 mg) improved memory/attention; 6-mo trial in geriatric cognitive decline; bacopa meta-analyses support…
In: Ultimate Brain
28-day RCTs: improved attention in healthy women (250/500 mg) and adolescent males; 12-wk RCT in older adults improved episodic memory (500…
In: Ultimate Brain
Acute crossover RCT (n=13, 200 mg): improved attention, reaction time, memory vs placebo; dose-response 50/100/200 mg; 7-day safety
In: Focus Fuel
Pilot RCT (n≈50) reported improved memory/processing scores at 150–300 mg (Prevagen-adjacent category); evidence
In: Ultimate Brain · Dopamine Boost
Five RCTs in systematic review: mild cognitive-impairment RCT (Mori 2009) positive; one null 12-wk RCT in adults >50 (LiverTox note);…
In: Ultimate Brain
6-wk RCT (n=100, 2 g/day) improved cognition composite (p=0.043) and sleep; 21-day sleep RCT (n=80) at 1 g/day; 12-wk older-adult cognition…
In: Sleep & Recovery · Ultimate Minerals
Small RCTs: improved sperm parameters and stress hormones in infertile men; dopaminergic effects; Parkinson pilot data (high
In: Dopamine Boost
Tyrosine (2 g) RCTs improve cognition under stress/sleep deprivation; NALT PK weaker than free tyrosine
In: Dopamine Boost
RCTs on fatigue, burnout symptoms and cognitive performance under stress (200–600 mg); Cochrane-level evidence
In: Dopamine Boost
PS 100–300 mg/day RCTs: memory in age-associated memory impairment, attention in children (2025 RCT, 100 mg sunflower PS); FDA qualified…
In: Ultimate Brain
Essential cofactor for dopamine decarboxylation; RDA-level
In: Dopamine Boost
Human data mostly via chamomile extracts (sleep quality in older adults, GAD trials); isolated apigenin RCTs limited; liposomal form chosen…
In: Sleep & Recovery
RCTs: reduced perceived stress/cortisol; 2024 Sci Rep RCT improved sleep quality and
In: Sleep & Recovery · Gut Biome
RCTs: improved sleep quality in elderly and postpartum women; GAD trial at 1,500
In: Sleep & Recovery
RCTs (3 g pre-bed) improved subjective sleep quality, next-day fatigue and core-temperature
In: Sleep & Recovery
Magnolia-bark RCTs on stress/sleep (combinations); isolated honokiol data preclinical (NREM +35–48% in rodents); GABA-A positive
In: Sleep & Recovery
RCTs at 150–300 mg: reduced stress markers and improved sleep in stressed
In: Sleep & Recovery
Double-blind RCT (n=103, 350 mg × 8 wk): faster sleep onset and better actigraphy outcomes vs
In: Sleep & Recovery
Magnesium RCTs improve sleep quality in older adults and insomnia; chelate form avoids
In: Sleep & Recovery · Ultimate Minerals
Systematic review of 13 trials (n=550, 50–900 mg): improved sleep-related outcomes; alpha-wave and attention RCTs at 50–200
In: Focus Fuel · Sleep & Recovery
RCT (n=32): pasteurized A. muciniphila 10^10/day × 3 mo improved insulin sensitivity and liver enzymes (Depommier 2019); Amansia weight…
In: Gut Biome
RCTs: IBS and GERD symptom reduction with inner-leaf
In: GI Repair
Spore-probiotic RCT (Bacillus blend) reduced post-prandial endotoxemia; B. coagulans IBS
In: Gut Biome
Animal GI-protection and tendon data extensive; human RCTs absent; oral gut-targeted use described in the
In: GI Repair
21-day RCT (n=32, 300 mg): microbiome shifts; in-vitro SHIME barrier/immune data
In: GI Repair
RCTs: dyspepsia/ulcer symptom
In: GI Repair
Colitis models (oral KPV reduces inflammation via PepT1); no human
In: GI Repair
RCTs: 5 g t.i.d. improved IBS-D with intestinal permeability; lower doses
In: GI Repair
Most-studied strain (antibiotic-associated diarrhea, atopic
In: Gut Biome
Psychobiotic RCTs (Tourette GI comorbidities 2026; athletes; mood); preclinical serotonin/dopamine
In: Gut Biome
Phase 2 RCTs in celiac disease reduced symptoms at 0.5 mg t.i.d.; phase 3 discontinued for futility
In: GI Repair
Dozens of RCTs (infant colic, H. pylori adjunct, bone density in older women
In: Gut Biome
Enteric buffer to protect peptides from gastric acid (formulation
In: GI Repair
RCTs: gastric mucosal protection, H. pylori adjunct (75 mg b.i.d.), NSAID gut injury, oral
In: GI Repair
RCTs in adults with IBS (2 g 2′-FL/LNnT × 4 wk) improved symptoms and
In: Gut Biome · Daily Digestion
RCTs: bifidogenic, IBS symptom relief; very well
In: Daily Digestion
RCT: reduced DOMS and improved recovery; digestive-comfort
In: Daily Digestion
Meta-analyses: nausea, gastric emptying,
In: Daily Digestion
RCTs on immune markers and cold symptoms with heat-killed
In: Gut Biome
Open-label and placebo-controlled trials (1.2–5 g) in IBS-D and HIV enteropathy; gut barrier
In: Daily Digestion
RCTs: reduced exercise-induced intestinal permeability and URTI; IgG content
In: Daily Digestion
RCTs: bowel regularity, IBS symptoms, sleep/motivation and cognition in elderly
In: Daily Digestion
RCTs/meta-analyses: depression adjunct, neuropathy, cognitive
In: Daily Detox
β-glucuronidase inhibition; rodent data only, no human
In: Daily Detox
Human PK: raised lymphocyte glutathione within hours; small trials
In: Daily Detox
Siliphos RCTs in NAFLD/ hepatitis improved enzymes; phytosome PK
In: Daily Detox
Decades of RCTs (glutathione precursor, mucolytic, psychiatric
In: Daily Detox
Lipophilic NAC prodrug with far higher oral bioavailability (PubMed 23000913); human RCTs absent
In: Daily Detox
RCTs: BP reduction (500 mg b.i.d. vs captopril), insulin sensitivity; hydroxytyrosol EFSA
In: Daily Detox
Essential-phospholipid trials in fatty liver and liver enzymes
In: Daily Detox
6-mo RCT (n=54): oral GSH 250/1,000 mg raised body stores and NK
In: Daily Detox
ALA RCTs: neuropathy symptoms, insulin sensitivity; R-form PK
In: Daily Detox
Sulforaphane RCTs: detox enzyme induction, autism behavior, H. pylori, airway inflammation (10–40
In: Daily Detox
Human trials in cholestasis/liver enzymes (500–1,500 mg) and insulin sensitivity (1,750 mg); supplement-dose RCTs
In: Daily Detox
12-wk RCT (900 mg) in trained men was NULL for strength/lean mass; GNE-myopathy pilots at 3–6 g; preclinical muscle
RCTs: lower RPE and faster gastric emptying vs maltodextrin; 30 g CrossFit acute trial; 2025 crossover
In: Ultimate Intra-Workout
Hundreds of RCTs/meta-analyses: strength, lean mass, cognition under sleep deprivation; ISSN position
In: Ultimate Morning · Muscle & Strength
Higher solubility; small RCTs show comparable lean-mass gains to monohydrate at lower
In: Muscle & Strength
Hydration/performance RCTs; sodium-containing beverages maintain plasma
In: Ultimate Morning · Ultimate Pre-Workout · Ultimate Intra-Workout
EAA 6–10 g RCTs stimulate MPS comparably to 20–25 g protein; intra-workout EAA
In: Ultimate Intra-Workout
Gold-standard protein for MPS; hundreds of
In: Grass-Fed Whey Isolate
RCTs: GAA 1.2–3 g raises muscle and brain creatine more than creatine; homocysteine rise mitigated by TMG/B
In: Muscle & Strength
Meta-analyses: 6–8 g improves high-intensity performance and reduces soreness; raises plasma arginine more than
In: Ultimate Pre-Workout
Clinical-nutrition RCTs (burns, surgery) on nitrogen balance; ornithine reduces ammonia/fatigue in exercise
In: Ultimate Pre-Workout
RCT: improved protein absorption with whey; IBS symptom
In: Grass-Fed Whey Isolate
8-wk RCT (n=28): PA 750 mg + resistance training increased lean mass and strength vs placebo; replication mixed
In: Muscle & Strength
RCTs: 400 mg acute improved lower-body resistance performance; 2-wk 3MT study; 12-wk lean-mass/strength
In: Ultimate Pre-Workout
3 RCTs at 2.4 g/day: strength +17–20%, improved recovery from disuse, bone-density signal in 56
In: Muscle & Strength · Grass-Fed Whey Isolate
RCT: increased amino-acid absorption from whey, reduced large-peptide
In: Grass-Fed Whey Isolate
12-mo RCT (n=131 postmenopausal women): 5 g/day raised lumbar and femoral-neck BMD T-scores vs
In: Ultimate Recovery
24-wk RCT (n=139 athletes) and 12-wk RCT (n=182): 5 g/day reduced activity-related knee/hip
In: Ultimate Recovery
RCTs: skin hydration (120 mg) and knee OA symptoms (oral
In: Ultimate Recovery
RCTs: 5 g/day improved Achilles tendinopathy outcomes and ankle stability in
In: Ultimate Recovery
Multiple RCTs (40 mg/day): knee flexibility and joint comfort in healthy adults and OA (superior to
In: Ultimate Recovery
RCTs (2.5 g × 8 wk): skin elasticity, wrinkles, cellulite,
In: Ultimate Recovery
Traditional Brazilian aphrodisiac; preclinical dopaminergic/antidepressant data; human RCTs
In: Forever Young
RCTs in China on memory and fatigue; TCM "desert ginseng"; androgen-support
In: Forever Young
Traditional African libido/sperm-motility herb; in-vitro sperm motility data; small human study
In: Forever Young
Traditional southern-African male-vitality herb; ethnobotanical and preclinical data
In: Forever Young
Khavinson bioregulator literature: open and controlled Russian trials on bone marrow-system function with cytomax peptides; hematopoietic…
In: BioRegulate Musculoskeletal
Khavinson bioregulator literature: open and controlled Russian trials on brain cortex-system function with cytomax peptides;…
In: BioRegulate Neuro
Khavinson bioregulator literature: open and controlled Russian trials on heart muscle-system function with cytomax peptides; cardiac…
In: BioRegulate Cardio
Khavinson bioregulator literature: open and controlled Russian trials on pineal gland-system function with cytomax peptides; melatonin…
In: BioRegulate Neuro · BioRegulate Immune-Endocrine · BioRegulate Female Vitality
Khavinson bioregulator literature: open and controlled Russian trials on adrenal-system function with cytomax peptides; stress-axis…
In: BioRegulate Immune-Endocrine · BioRegulate Male Vitality
Khavinson bioregulator literature: open and controlled Russian trials on skeletal muscle-system function with cytomax peptides;…
In: BioRegulate Musculoskeletal
Khavinson bioregulator literature: open and controlled Russian trials on prostate-system function with cytomax peptides; prostate-function…
In: BioRegulate Male Vitality
DRcaps dissolution data (delayed gastric release); liposomal peptide-protection rationale; the "novel bioavailable formulation"
BioMale-style cofactor; ALA RCT
In: BioRegulate Neuro · BioRegulate Cardio · BioRegulate Immune-Endocrine · BioRegulate Male Vitality · BioRegulate Female Vitality · BioRegulate Musculoskeletal
Khavinson bioregulator literature: open and controlled Russian trials on cartilage-system function with cytomax peptides; joint-function…
In: BioRegulate Musculoskeletal
Khavinson bioregulator literature: open and controlled Russian trials on liver-system function with cytomax peptides; hepatic function…
In: BioRegulate Cardio
Khavinson bioregulator literature: open and controlled Russian trials on testes-system function with cytomax peptides; spermatogenesis and…
In: BioRegulate Male Vitality
Khavinson bioregulator literature: open and controlled Russian trials on thyroid-system function with cytomax peptides; thyroid-function…
In: BioRegulate Immune-Endocrine · BioRegulate Female Vitality
Khavinson bioregulator literature: open and controlled Russian trials on blood vessel-system function with cytomax peptides; vascular…
In: BioRegulate Neuro · BioRegulate Cardio · BioRegulate Male Vitality · BioRegulate Female Vitality · BioRegulate Musculoskeletal
Khavinson bioregulator literature: open and controlled Russian trials on thymus-system function with cytomax peptides; immune-aging…
In: BioRegulate Immune-Endocrine
Khavinson bioregulator literature: open and controlled Russian trials on ovary-system function with cytomax peptides; female…
In: BioRegulate Female Vitality
RCTs: BP and coronary calcium progression
RCT/open trials: HPV clearance, NK activity; 3
Rat lifespan study (Baati 2012) never replicated; no human
Berberine meta-analyses (HbA1c, lipids); DHB PK 5× — but user irritant rule: standalone
Melatonin meta-analyses for sleep onset/jet lag; plant-derived
Epidemiology on trace lithium and mortality/dementia; low-dose RCTs small — offered standalone
RCTs: galectin-3, PSA doubling time, heavy-metal excretion
Nattokinase RCTs (BP, fibrinolysis); serrapeptase
These statements have not been evaluated by the Food and Drug Administration. These products are not intended to diagnose, treat, cure or prevent any disease. Nothing on this site is medical advice — it is educational "what I would do if I were you" guidance from an executive health coach. Talk with your clinician before starting any supplement, especially if you take medication, are pregnant or nursing, or have a medical condition. *Formulations are unofficial — Version 2.0 specifications are being finalized ahead of the first single-batch run and may change before release. Supplement Facts shown are the current design targets, not a finished label.
A one-hour, one-on-one session with Jason Johns that ends with your own customized edition of The Ultimate Handbook of Health: detailed, personalized protocols including peptides, bioregulators, and highly specific supplement timing and an interactions checker — a stack designed for your biology and taken when it can actually be absorbed.