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11 published human trials; 237-pt RCT at 500/1,000 mg × 30 d improved total/LDL cholesterol, TG and glucose vs placebo; 77-pt trial with rosuvastatin add-on.
8/10evidence score
HP Ingredients / H&ADlicensed form owner
500 mgstudied dose used
What the evidence shows
11 published human trials; 237-pt RCT at 500/1,000 mg × 30 d improved total/LDL cholesterol, TG and glucose vs placebo; 77-pt trial with rosuvastatin add-on.
Tier is our appraisal of the human evidence at the dose we use: Tier 1 = multiple randomized trials; Tier 2 = human trials, fewer or smaller; Tier 3 = mechanistic, traditional or early human data; Tier 4 = emerging. Ingredients below Tier 2 are included only where the safety record is long and the traditional use is specific.
Form and dose
Form used
Citrus bergamia fruit extract, ≥38% polyphenols
Branded source
HP Ingredients / H&AD
Dose per serving
500 mg
Delivery
Standard / as studied
Who should be careful
Possible additive effect with statins (monitor); GI upset rare. Talk with your clinician before starting if any of this applies to you.
Which NEX-GEN formulas contain Bergamonte® bergamot polyphenolic fraction (38% BPF)?
Ultimate Heart (500 mg per serving). Every formula lists its full dose on the Supplement Facts panel — no proprietary blends.
What form of Bergamonte® bergamot polyphenolic fraction does NEX-GEN use and why?
Citrus bergamia fruit extract, ≥38% polyphenols. We use the licensed branded form so the dose on our label matches the material studied in the trials.
What does the evidence actually show for Bergamonte® bergamot polyphenolic fraction?
11 published human trials; 237-pt RCT at 500/1,000 mg × 30 d improved total/LDL cholesterol, TG and glucose vs placebo; 77-pt trial with rosuvastatin add-on.
Who should be careful with it?
Possible additive effect with statins (monitor); GI upset rare. Talk with your clinician before starting if any of this applies to you.
These statements have not been evaluated by the Food and Drug Administration. These products are not intended to diagnose, treat, cure or prevent any disease. Nothing on this site is medical advice — it is educational "what I would do if I were you" guidance from an executive health coach. Talk with your clinician before starting any supplement, especially if you take medication, are pregnant or nursing, or have a medical condition. Last reviewed October 2026.
The protocols we cannot publish here
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