Formulas built the way I would build them for myself.
Version 2.0Single-batch runChangelog
Lipids · endothelium · mitochondrial fuel
Nine clinically studied, licensed branded cardio-lipid ingredients in one four-capsule serving — the formula Jason takes with lunch.
$179 $152/mo on subscription · from $134/unit on a 3-pack subscription
No payment is collected today — pre-orders are saved to your list and confirmed by email. Checkout opens January 1, 2027. How pricing works.
No proprietary blends. Each line below is on the Supplement Facts panel at exactly this amount. Tier is our appraisal of the human evidence; sources are linked.
Evidence. 11 published human trials; 237-pt RCT at 500/1,000 mg × 30 d improved total/LDL cholesterol, TG and glucose vs placebo; 77-pt trial with rosuvastatin add-on.
Cautions. Possible additive effect with statins (monitor); GI upset rare.
bergamonte.net/the-science/clinical-studi…hpingredients.com/products/premier-ingred…
Evidence. 50+ years of trials; FDA-authorized health claim at ≥0.8 g/day plant sterols for reduced CHD risk; LDL −8–10% at 2 g/day.
Cautions. Reduces carotenoid absorption (DAKE formula compensates); not for sitosterolemia.
adm.com/en-us/products-services/human-nut…knowde.com/stores/adm/products/cardioaid-…
Evidence. 28 trials (median 900 mg/day) lowered TC −8.7–15.1% and LDL −10–20%; triple-blind RCT at 600 mg/day: LDL −11% vs placebo in statin-eligible adults.
Cautions. Mild GI effects; additive with lipid drugs.
pantesin.com/uploads/news-pdfs/Pantesin-i…ods.od.nih.gov/factsheets/PantothenicAcid…pantesin.com/news/2014/new-study-shows-th…
Evidence. Two open-label 4-wk pilots (n=10 each) and a 12-wk RCT (n=120) at 300 mg/day: TC −27% vs placebo; LDL and TG reductions.
Cautions. None significant reported; tocotrienol content adds to DeltaGold® (keep total tocotrienols <500 mg).
ingredientsbynature.com/storage/app/media…lifeextension.com/magazine/2004/11/report…
Evidence. 250 mg/day δ-tocotrienol improved lipid and inflammatory markers in several small RCTs (n≈31–60); 14-day crossover raised plasma δ-T3 and lowered lipids.
Cautions. Avoid combining with high α-tocopherol (interferes); additive bleeding risk with anticoagulants theoretical.
pmc.ncbi.nlm.nih.gov/articles/PMC11782774/nutraingredients-usa.com/Article/2015/07/…
Evidence. RCT in 60 treated hypertensives: standardized tomato extract (15 mg lycopene) lowered systolic BP and improved endothelial markers; prehypertension crossover trial.
Cautions. None significant; carotenoid absorption is reduced by plant sterols — pair with fat-containing meal.
academic.oup.com/ajh/article/18/S4/213A/136943link.springer.com/article/10.1186/1472-68…
Evidence. Artichoke leaf extract meta-analyses show modest LDL/TG reduction; ginger lowers TG in small RCTs. Combination data limited to the branded pilot.
Cautions. Bile-duct obstruction contraindication (artichoke); ginger additive with anticoagulants.
pubmed.ncbi.nlm.nih.gov/?term=artichoke+l…pubmed.ncbi.nlm.nih.gov/?term=ginger+trig…
Evidence. CoQ10 RCTs/meta-analyses: improved endothelial function and reduced statin-associated muscle symptoms; MicroActive form shows universal absorption in PK studies.
Cautions. May reduce warfarin effect; mild GI.
pubmed.ncbi.nlm.nih.gov/?term=coenzyme+Q1…nhc.com/learning-resources/emerging-new-i…
Evidence. Human pilot data on statin-associated muscle symptoms and testosterone support in men on statins; mechanistic rationale (mevalonate pathway).
Cautions. None established; theoretical additive with CoQ10 (desired).
Serving size 4 capsules
Servings per container 30
| Amount per serving | % DV | |
|---|---|---|
| Bergamonte® bergamot polyphenolic fraction (38% BPF) | 500 mg | † |
| CardioAid® plant sterols | 400 mg | † |
| Pantesin® pantethine | 300 mg | † |
| Sytrinol® citrus PMFs + palm tocotrienols | 150 mg | † |
| DeltaGold® annatto tocotrienols (90% δ / 10% γ) | 125 mg | † |
| Lyc-O-Mato® tomato complex (6% lycopene) | 250 mg | † |
| Artichoke leaf (5% cynarin) + ginger root (5% gingerols) complex | 200 mg | † |
| MicroActive® CoQ10 (24-hour sustained release) | 100 mg | † |
| Geranylgeraniol (GG-Gold®, from annatto) | 50 mg | † |
† Daily Value not established. Percent Daily Values are based on a 2,000-calorie diet.
Other ingredients: plant-based capsule (pullulan), sunflower lecithin (liposomal carrier), rice hull concentrate.
Directions: Take 4 capsules once daily with your largest meal (fat improves carotenoid and tocotrienol absorption).
*Formulations are unofficial — Version 2.0 specifications are being finalized ahead of the first single-batch run and may change before release. Supplement Facts shown are the current design targets, not a finished label.
Matte black label on amber glass with metallic blue edges. Final artwork is proofed before the first run.
| One-time | |
| Subscribe monthly | $152 |
| 3-pack | $143/unit |
| 3-pack subscription | $134/unit |
Stack it with up to four other formulas for 5–25% more off every rung. Build a stack →
Buy a 3-pack (one-time or subscription), complete four short surveys over 90 days, and earn back 25% of what you paid as store credit — or 40% as subscription credit. Self-reported, published in aggregate, never called a clinical trial.
How it worksVersion 2.0 is made once. When this batch sells out it is gone; the next version is announced before it is made. If this formula is working for you, tell us to keep it — and buy a few extra bottles just in case.
Read the changelogPlant sterols compete with cholesterol for absorption in the gut, while bergamot polyphenols act on how the liver handles cholesterol and glucose — two complementary ways of supporting cholesterol levels already within the normal range.*
Several of these ingredients have been studied alongside statins, but talk with your physician first — the combination may lower lipids more than expected.
Every NEX-GEN formula starts at Version 2.0 and later versions may be announced each quarter. Each run is a single batch — once it sells out, that exact version is retired. If you love a version, tell us to keep it, and buy a few extra bottles just in case.
Pre-order adds the item to your saved cart and emails a confirmation that your bottles are reserved. No payment is taken now; you will be prompted to complete checkout when the Version 2.0 batch releases in early 2027.
Version 2.0 ships early 2027 in the order pre-orders were placed. Pre-orders open January 1, 2027; until then you can save it to your list at no cost.
These statements have not been evaluated by the Food and Drug Administration. These products are not intended to diagnose, treat, cure or prevent any disease. Nothing on this site is medical advice — it is educational "what I would do if I were you" guidance from an executive health coach. Talk with your clinician before starting any supplement, especially if you take medication, are pregnant or nursing, or have a medical condition.
Nitric oxide · glycocalyx · daily endothelial support
$189 $161/mo on subscription · from $142/unit on a 3-pack subscription
Methylated Bs · liposomal C · cocoa flavanols · electrolytes · fulvic
$99 $84/mo on subscription · from $74/unit on a 3-pack subscription
D3 · A · K1/K2 · tocotrienol E · astaxanthin · lutein · saffron · LPC-omega-3
$129 $110/mo on subscription · from $97/unit on a 3-pack subscription
A one-hour, one-on-one session with Jason Johns that ends with your own customized edition of The Ultimate Handbook of Health: detailed, personalized protocols including peptides, bioregulators, and highly specific supplement timing and an interactions checker — a stack designed for your biology and taken when it can actually be absorbed.
