Evidence. Placebo-controlled 90-day trial: improved flow-mediated dilation and blood pressure (Vaisman 2015); acute FMD and PK studies.
Cautions. None significant; additive with antihypertensives.

Formulas built the way I would build them for myself.

Version 2.0Single-batch runChangelog
Nitric oxide · glycocalyx · daily endothelial support
A daily, stimulant-free vascular formula: VINIA®, Pycnogenol®, Nitrosigine® and OXYSTORM® nitrate with glycocalyx-supporting rhamnan sulfate.
$189 $161/mo on subscription · from $142/unit on a 3-pack subscription
No payment is collected today — pre-orders are saved to your list and confirmed by email. Checkout opens January 1, 2027. How pricing works.
No proprietary blends. Each line below is on the Supplement Facts panel at exactly this amount. Tier is our appraisal of the human evidence; sources are linked.
Evidence. Placebo-controlled 90-day trial: improved flow-mediated dilation and blood pressure (Vaisman 2015); acute FMD and PK studies.
Cautions. None significant; additive with antihypertensives.
Evidence. Randomized double-blind crossover (Enseleit, Eur Heart J): improved endothelial function in CAD patients at 200 mg; 100 mg/day improved FMD in healthy adults; >160 trials.
Cautions. Mild GI; theoretical additive with antiplatelets.
frontiersin.org/journals/nutrition/articl…pycnogenol.com/fileadmin/pdf/Application_…
Evidence. Glycocalyx-support ingredient; small human studies (microvascular perfusion, plaque imaging) sponsored by Calroy; mechanistic rationale strong.
Cautions. Theoretical anticoagulant additive (heparin-like) — avoid with anticoagulants.
oakwaynaturals.com/content/designs_for_he…microvascular.com/wp-content/uploads/2022…
Evidence. Multiple RCTs at 1.5 g: raised plasma arginine/NO markers for 6 h; improved post-exercise cognitive flexibility; blood-flow and muscle-pump outcomes.
Cautions. None significant.
pmc.ncbi.nlm.nih.gov/articles/PMC5133120/nutraceuticalsworld.com/breaking-news/nit…
Evidence. Sea buckthorn proanthocyanidins: biomarker trials on vascular and skin outcomes; limited branded human data.
Cautions. None significant.
Evidence. RCT (n=16): 2 g raised plasma/salivary nitrate-nitrite; 1 g raised calf blood flow at 30 min and delayed ventilatory threshold; 7–15-day intake improved 4-km TT and time-to-exhaustion (~19%).
Cautions. Avoid with PDE-5 inhibitors or nitrate drugs (additive hypotension); mouthwash blunts conversion.
nctcorpo.com/en/products/oxystorm.htmlmdpi.com/1422-0067/25/7/3650barlowesherbalelixirs.com/oxystorm-red-sp…
Serving size 3 capsules
Servings per container 30
| Amount per serving | % DV | |
|---|---|---|
| VINIA® red grape cell powder (piceid resveratrol) | 400 mg | † |
| Pycnogenol® French maritime pine bark extract | 100 mg | † |
| Rhamnan sulfate (Monostroma nitidum seaweed extract) | 150 mg | † |
| Nitrosigine® inositol-stabilized arginine silicate | 500 mg | † |
| CyanthOx30™ sea buckthorn (30% proanthocyanidins) | 300 mg | † |
| OXYSTORM® red spinach extract (9% nitrate) | 250 mg | † |
† Daily Value not established. Percent Daily Values are based on a 2,000-calorie diet.
Other ingredients: plant-based capsule (pullulan), sunflower lecithin (liposomal carrier), rice hull concentrate.
Directions: Take 3 capsules daily on an empty stomach, or 60 minutes before activity. Avoid antiseptic mouthwash within 2 hours (it blocks nitrate conversion).
*Formulations are unofficial — Version 2.0 specifications are being finalized ahead of the first single-batch run and may change before release. Supplement Facts shown are the current design targets, not a finished label.




Matte black label on amber glass with metallic blue edges. Final artwork is proofed before the first run.
| One-time | |
| Subscribe monthly | $161 |
| 3-pack | $151/unit |
| 3-pack subscription | $142/unit |
Stack it with up to four other formulas for 5–25% more off every rung. Build a stack →
Buy a 3-pack (one-time or subscription), complete four short surveys over 90 days, and earn back 25% of what you paid as store credit — or 40% as subscription credit. Self-reported, published in aggregate, never called a clinical trial.
How it worksVersion 2.0 is made once. When this batch sells out it is gone; the next version is announced before it is made. If this formula is working for you, tell us to keep it — and buy a few extra bottles just in case.
Read the changelogNo — Ultimate Pre-Workout carries the full 1 g OXYSTORM® dose plus citrulline and PeakATP®. Blood Flow is the daily vascular-health formula you take even on rest days.
Every NEX-GEN formula starts at Version 2.0 and later versions may be announced each quarter. Each run is a single batch — once it sells out, that exact version is retired. If you love a version, tell us to keep it, and buy a few extra bottles just in case.
Pre-order adds the item to your saved cart and emails a confirmation that your bottles are reserved. No payment is taken now; you will be prompted to complete checkout when the Version 2.0 batch releases in early 2027.
Version 2.0 ships early 2027 in the order pre-orders were placed. Pre-orders open January 1, 2027; until then you can save it to your list at no cost.
These statements have not been evaluated by the Food and Drug Administration. These products are not intended to diagnose, treat, cure or prevent any disease. Nothing on this site is medical advice — it is educational "what I would do if I were you" guidance from an executive health coach. Talk with your clinician before starting any supplement, especially if you take medication, are pregnant or nursing, or have a medical condition.
Lipids · endothelium · mitochondrial fuel
$179 $152/mo on subscription · from $134/unit on a 3-pack subscription
Methylated Bs · liposomal C · cocoa flavanols · electrolytes · fulvic
$99 $84/mo on subscription · from $74/unit on a 3-pack subscription
D3 · A · K1/K2 · tocotrienol E · astaxanthin · lutein · saffron · LPC-omega-3
$129 $110/mo on subscription · from $97/unit on a 3-pack subscription
A one-hour, one-on-one session with Jason Johns that ends with your own customized edition of The Ultimate Handbook of Health: detailed, personalized protocols including peptides, bioregulators, and highly specific supplement timing and an interactions checker — a stack designed for your biology and taken when it can actually be absorbed.



















