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Multiple RCTs at 1.5 g: raised plasma arginine/NO markers for 6 h; improved post-exercise cognitive flexibility; blood-flow and muscle-pump outcomes.
7/10evidence score
Nutrition21licensed form owner
750 mgstudied dose used
What the evidence shows
Multiple RCTs at 1.5 g: raised plasma arginine/NO markers for 6 h; improved post-exercise cognitive flexibility; blood-flow and muscle-pump outcomes.
Tier is our appraisal of the human evidence at the dose we use: Tier 1 = multiple randomized trials; Tier 2 = human trials, fewer or smaller; Tier 3 = mechanistic, traditional or early human data; Tier 4 = emerging. Ingredients below Tier 2 are included only where the safety record is long and the traditional use is specific.
Form and dose
Form used
ASI, 1,500 mg studied
Branded source
Nutrition21
Dose per serving
750 mg
Delivery
Standard / as studied
Who should be careful
None significant. Talk with your clinician before starting if any of this applies to you.
Which NEX-GEN formulas contain Nitrosigine® inositol-stabilized arginine silicate?
Ultimate Blood Flow (500 mg per serving) · Ultimate Pre-Workout (750 mg per serving). Every formula lists its full dose on the Supplement Facts panel — no proprietary blends.
What form of Nitrosigine® inositol-stabilized arginine silicate does NEX-GEN use and why?
ASI, 1,500 mg studied. We use the licensed branded form so the dose on our label matches the material studied in the trials.
What does the evidence actually show for Nitrosigine® inositol-stabilized arginine silicate?
Multiple RCTs at 1.5 g: raised plasma arginine/NO markers for 6 h; improved post-exercise cognitive flexibility; blood-flow and muscle-pump outcomes.
Who should be careful with it?
None significant. Talk with your clinician before starting if any of this applies to you.
These statements have not been evaluated by the Food and Drug Administration. These products are not intended to diagnose, treat, cure or prevent any disease. Nothing on this site is medical advice — it is educational "what I would do if I were you" guidance from an executive health coach. Talk with your clinician before starting any supplement, especially if you take medication, are pregnant or nursing, or have a medical condition. Last reviewed October 2026.
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