Version 2.0 formulas releasing soon · Single batch every time — every batch reformulated and matched to the latest scientific evidence · 166 evidence-based compounds across 30 products.Version 2.0 releasing soon · Single batch every time · 166 compounds across 30 products.
Formulas built the way I would build them for myself.
Tier 1 · multiple human RCTsStandalone candidate · not in a Version 2.0 formula
Dihydroberberine (GlucoVantage®)
Berberine meta-analyses (HbA1c, lipids); DHB PK 5× — but user irritant rule: standalone only.
9/10evidence score
NNB Nutritionlicensed form owner
150 mgstudied dose used
What the evidence shows
Berberine meta-analyses (HbA1c, lipids); DHB PK 5× — but user irritant rule: standalone only.
Tier is our appraisal of the human evidence at the dose we use: Tier 1 = multiple randomized trials; Tier 2 = human trials, fewer or smaller; Tier 3 = mechanistic, traditional or early human data; Tier 4 = emerging. Ingredients below Tier 2 are included only where the safety record is long and the traditional use is specific.
Form and dose
Form used
DHB 100–200 mg
Branded source
NNB Nutrition
Dose per serving
150 mg
Delivery
Standard / as studied
Who should be careful
GI; CYP3A4; not with cyclosporine. Talk with your clinician before starting if any of this applies to you.
In our formulas
Not in a Version 2.0 formula. This is a standalone candidate — usually because it is best dosed alone, with meals, or cycled. Tell us if you want it as a single-ingredient bottle; standalone SKUs are decided by demand.
FAQ
Is Dihydroberberine (GlucoVantage®) in a NEX-GEN formula yet?
Not in Version 2.0. It is a standalone candidate — an ingredient we rate highly but keep out of the combination formulas (usually because it is best dosed alone, with meals, or cycled). If you want it as a single-ingredient bottle, tell us on the contact page; standalone SKUs are decided by demand.
What form of Dihydroberberine does NEX-GEN use and why?
DHB 100–200 mg. We use the licensed branded form so the dose on our label matches the material studied in the trials.
What does the evidence actually show for Dihydroberberine?
Berberine meta-analyses (HbA1c, lipids); DHB PK 5× — but user irritant rule: standalone only.
Who should be careful with it?
GI; CYP3A4; not with cyclosporine. Talk with your clinician before starting if any of this applies to you.
These statements have not been evaluated by the Food and Drug Administration. These products are not intended to diagnose, treat, cure or prevent any disease. Nothing on this site is medical advice — it is educational "what I would do if I were you" guidance from an executive health coach. Talk with your clinician before starting any supplement, especially if you take medication, are pregnant or nursing, or have a medical condition. Last reviewed October 2026.
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