Version 2.0 formulas releasing soon · Single batch every time — every batch reformulated and matched to the latest scientific evidence · 166 evidence-based compounds across 30 products.Version 2.0 releasing soon · Single batch every time · 166 compounds across 30 products.
Formulas built the way I would build them for myself.
Tier 3 · mechanistic / traditional / early human
Lion's mane (Hericium erinaceus) fruiting body + mycelium 8:1, erinacine-A standardized
Five RCTs in systematic review: mild cognitive-impairment RCT (Mori 2009) positive; one null 12-wk RCT in adults >50 (LiverTox note); erinacine-A trials in Taiwan positive.
6/10evidence score
500 mgstudied dose used
What the evidence shows
Five RCTs in systematic review: mild cognitive-impairment RCT (Mori 2009) positive; one null 12-wk RCT in adults >50 (LiverTox note); erinacine-A trials in Taiwan positive.
Tier is our appraisal of the human evidence at the dose we use: Tier 1 = multiple randomized trials; Tier 2 = human trials, fewer or smaller; Tier 3 = mechanistic, traditional or early human data; Tier 4 = emerging. Ingredients below Tier 2 are included only where the safety record is long and the traditional use is specific.
Form and dose
Form used
≥30% β-glucans, erinacine A ≥0.5%
Dose per serving
500 mg
Delivery
Standard / as studied
Who should be careful
Rare hepatotoxicity reports (LiverTox grade); mushroom allergy. Talk with your clinician before starting if any of this applies to you.
Which NEX-GEN formulas contain Lion's mane (Hericium erinaceus) fruiting body + mycelium 8:1, erinacine-A standardized?
Ultimate Brain (500 mg per serving). Every formula lists its full dose on the Supplement Facts panel — no proprietary blends.
What form of Lion's mane does NEX-GEN use and why?
≥30% β-glucans, erinacine A ≥0.5%. We choose the most bioavailable form we can source at the studied dose.
What does the evidence actually show for Lion's mane?
Five RCTs in systematic review: mild cognitive-impairment RCT (Mori 2009) positive; one null 12-wk RCT in adults >50 (LiverTox note); erinacine-A trials in Taiwan positive.
Who should be careful with it?
Rare hepatotoxicity reports (LiverTox grade); mushroom allergy. Talk with your clinician before starting if any of this applies to you.
These statements have not been evaluated by the Food and Drug Administration. These products are not intended to diagnose, treat, cure or prevent any disease. Nothing on this site is medical advice — it is educational "what I would do if I were you" guidance from an executive health coach. Talk with your clinician before starting any supplement, especially if you take medication, are pregnant or nursing, or have a medical condition. Last reviewed October 2026.
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