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On this page
Evidence Form & dose Cautions In our formulas FAQ Sources
Tier 2 · human trials, fewer or smaller
Bacillus subtilis HU58™ + B. coagulans (spore blend)
Spore-probiotic RCT (Bacillus blend) reduced post-prandial endotoxemia; B. coagulans IBS RCTs.
7 /10 evidence score
Microbiome Labs / Sabinsa licensed form owner
4 B CFU studied dose used
What the evidence shows Spore-probiotic RCT (Bacillus blend) reduced post-prandial endotoxemia; B. coagulans IBS RCTs.
Tier is our appraisal of the human evidence at the dose we use: Tier 1 = multiple randomized trials; Tier 2 = human trials, fewer or smaller; Tier 3 = mechanistic, traditional or early human data; Tier 4 = emerging. Ingredients below Tier 2 are included only where the safety record is long and the traditional use is specific.
Who should be careful None. Talk with your clinician before starting if any of this applies to you.
FAQ Which NEX-GEN formulas contain Bacillus subtilis HU58™ + B. coagulans (spore blend)? Gut Biome (4 billion CFU per serving). Every formula lists its full dose on the Supplement Facts panel — no proprietary blends.
What form of Bacillus subtilis HU58™ + B. coagulans does NEX-GEN use and why? 4 B CFU spores. We use the licensed branded form so the dose on our label matches the material studied in the trials.
What does the evidence actually show for Bacillus subtilis HU58™ + B. coagulans? Spore-probiotic RCT (Bacillus blend) reduced post-prandial endotoxemia; B. coagulans IBS RCTs.
Who should be careful with it? None. Talk with your clinician before starting if any of this applies to you.
These statements have not been evaluated by the Food and Drug Administration. These products are not intended to diagnose, treat, cure or prevent any disease. Nothing on this site is medical advice — it is educational "what I would do if I were you" guidance from an executive health coach. Talk with your clinician before starting any supplement, especially if you take medication, are pregnant or nursing, or have a medical condition. Last reviewed October 2026.
