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Tier 4 · emerging
5-Amino-1MQ (5-amino-1-methylquinolinium)
Rodent studies: NNMT inhibition reduced adipose mass and improved insulin sensitivity in diet-induced obesity, raised NAD+ and activated muscle stem cells in aged mice; no human trials published. Consumer capsules are 50–100 mg; often paired with ATX-304 (reference formulas use 75 mg alongside 100 mg ATX-304).
3/10evidence score
White-label APIlicensed form owner
50 mgstudied dose used
What the evidence shows
Rodent studies: NNMT inhibition reduced adipose mass and improved insulin sensitivity in diet-induced obesity, raised NAD+ and activated muscle stem cells in aged mice; no human trials published. Consumer capsules are 50–100 mg; often paired with ATX-304 (reference formulas use 75 mg alongside 100 mg ATX-304).
Tier is our appraisal of the human evidence at the dose we use: Tier 1 = multiple randomized trials; Tier 2 = human trials, fewer or smaller; Tier 3 = mechanistic, traditional or early human data; Tier 4 = emerging. Ingredients below Tier 2 are included only where the safety record is long and the traditional use is specific.
Form and dose
Form used
5-Amino-1MQ ≥98% (HPLC)
Branded source
White-label API
Dose per serving
50 mg
Delivery
Standard / as studied
Who should be careful
No human safety data; unknown drug interactions; not in pregnancy or nursing; cycle 8–12 weeks on / equal time off. Talk with your clinician before starting if any of this applies to you.
Which NEX-GEN formulas contain 5-Amino-1MQ (5-amino-1-methylquinolinium)?
NNMT · 5-Amino-1MQ (50 mg per serving). Every formula lists its full dose on the Supplement Facts panel — no proprietary blends.
What form of 5-Amino-1MQ does NEX-GEN use and why?
5-Amino-1MQ ≥98% (HPLC). We use the licensed branded form so the dose on our label matches the material studied in the trials.
What does the evidence actually show for 5-Amino-1MQ?
Rodent studies: NNMT inhibition reduced adipose mass and improved insulin sensitivity in diet-induced obesity, raised NAD+ and activated muscle stem cells in aged mice; no human trials published. Consumer capsules are 50–100 mg; often paired with ATX-304 (reference formulas use 75 mg alongside 100 mg ATX-304).
Who should be careful with it?
No human safety data; unknown drug interactions; not in pregnancy or nursing; cycle 8–12 weeks on / equal time off. Talk with your clinician before starting if any of this applies to you.
These statements have not been evaluated by the Food and Drug Administration. These products are not intended to diagnose, treat, cure or prevent any disease. Nothing on this site is medical advice — it is educational "what I would do if I were you" guidance from an executive health coach. Talk with your clinician before starting any supplement, especially if you take medication, are pregnant or nursing, or have a medical condition. Last reviewed October 2026.
The protocols we cannot publish here
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