Skip to content
Version 2.0 formulas releasing soon · Single batch every time — every batch reformulated and matched to the latest scientific evidence · 166 evidence-based compounds across 30 products.Version 2.0 releasing soon · Single batch every time · 166 compounds across 30 products.
NEX-GEN™
Build your stack

Formulas built the way I would build them for myself.

Tier 2 · human trials, fewer or smallerStandalone candidate · not in a Version 2.0 formula

AHCC® (Amino Up)

RCT/open trials: HPV clearance, NK activity; 3 g/day.

7/10evidence score
Amino Uplicensed form owner
3000 mgstudied dose used

What the evidence shows

RCT/open trials: HPV clearance, NK activity; 3 g/day.

Tier is our appraisal of the human evidence at the dose we use: Tier 1 = multiple randomized trials; Tier 2 = human trials, fewer or smaller; Tier 3 = mechanistic, traditional or early human data; Tier 4 = emerging. Ingredients below Tier 2 are included only where the safety record is long and the traditional use is specific.

Form and dose

Form used
Shiitake mycelia extract 3 g/day
Branded source
Amino Up
Dose per serving
3000 mg
Delivery
Standard / as studied

Who should be careful

Bulky dose; cycled use — standalone. Talk with your clinician before starting if any of this applies to you.

In our formulas

Not in a Version 2.0 formula. This is a standalone candidate — usually because it is best dosed alone, with meals, or cycled. Tell us if you want it as a single-ingredient bottle; standalone SKUs are decided by demand.

FAQ

Is AHCC® (Amino Up) in a NEX-GEN formula yet?

Not in Version 2.0. It is a standalone candidate — an ingredient we rate highly but keep out of the combination formulas (usually because it is best dosed alone, with meals, or cycled). If you want it as a single-ingredient bottle, tell us on the contact page; standalone SKUs are decided by demand.

What form of AHCC® does NEX-GEN use and why?

Shiitake mycelia extract 3 g/day. We use the licensed branded form so the dose on our label matches the material studied in the trials.

What does the evidence actually show for AHCC®?

RCT/open trials: HPV clearance, NK activity; 3 g/day.

Who should be careful with it?

Bulky dose; cycled use — standalone. Talk with your clinician before starting if any of this applies to you.

Sources

These statements have not been evaluated by the Food and Drug Administration. These products are not intended to diagnose, treat, cure or prevent any disease. Nothing on this site is medical advice — it is educational "what I would do if I were you" guidance from an executive health coach. Talk with your clinician before starting any supplement, especially if you take medication, are pregnant or nursing, or have a medical condition. Last reviewed October 2026.

The Ultimate Handbook of Health — cover
The protocols we cannot publish here

Book a “What I Would Do If I Were You” consultation

A one-hour, one-on-one session with Jason Johns that ends with your own customized edition of The Ultimate Handbook of Health: detailed, personalized protocols including peptides, bioregulators, and highly specific supplement timing and an interactions checker — a stack designed for your biology and taken when it can actually be absorbed.

  • Full review of your goals, labs and current stack
  • Customized Handbook (Version 2.0 — now with infographics) written for you
  • Sourcing guidance and what to track at each follow-up